J Korean Ophthalmol Soc.  2020 Feb;61(2):183-189. 10.3341/jkos.2020.61.2.183.

Bromfenac as Adjunctive Treatment with Intravitreal Bevacizumab in Branch Retinal Vein Occlusion of Macular Edema

• Yun JM
• Cho YW
• Moon JW

• KMID: 2470741
• DOI: http://doi.org/10.3341/jkos.2020.61.2.183

Abstract

PURPOSE
To evaluate the effectiveness of 0.1% topical bromfenac as an adjunctive treatment with intravitreal bevacizumab (IVB) injection for branch retinal vein occlusion (BRVO) patients.
METHODS
We retrospectively evaluated 68 eyes of 68 patients with macular edema (ME) secondary to BRVO who were treated with IVB injection and followed up for at least 12 months. Of the 68 eyes, 38 were treated with IVB combined with 0.1% topical bromfenac and 30 were treated with IVB alone. IVB reinjection was performed in cases of recurrence. The primary outcome measurement was the number of IVB injections. Changes in the best-corrected visual acuity (BCVA) and central foveal thickness (CFT) during the 12-month follow-up were compared.
RESULTS
There was no significant difference in the BCVA or CFT between the two groups at the initial and final examinations. However, the number of IVB injections was significantly lower in the 0.1% bromfenac-treated eyes (p < 0.01) than in the control eyes (4.1 ± 0.7 vs. 5.0 ± 0.6 times).
CONCLUSIONS
Compared to IVB monotherapy, topical bromfenac as an adjunctive treatment with IVB injection of eyes with ME secondary to BRVO did not affect visual outcomes, but it reduced the number of IVB injections.

Keyword

Bevacizumab; Branch retinal vein occlusion; Macular edema; Nonsteroidal anti-inflammatory drug (NSAIDs)

MeSH Terms

Bevacizumab*
Follow-Up Studies
Humans
Macular Edema*
Recurrence
Retinal Vein Occlusion*
Retinal Vein*
Retinaldehyde*
Retrospective Studies
Visual Acuity
Bevacizumab
Retinaldehyde

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