Korean J Dent Mater.  2019 Dec;46(4):215-228. 10.14815/kjdm.2019.46.4.215.

3D architecture developments for spatial controls of periodontal ligament regeneration with angular orientations

• Park CH

• KMID: 2470302
• DOI: http://doi.org/10.14815/kjdm.2019.46.4.215

Abstract

Various biomaterial-based, 3D architectures with micron-scaled geometries have been investigated for periodontal tissue neogenesis, and appropriate fabrication techniques for the scaffold manufacturing have been developed for pre-clinical or clinical situations. Periodontal tissues, the periodontal ligaments (PDLs), which are fibrous connective tissues between alveolar bone and cementum has been known as the major component that would generate biomechanical responses against mastication and occlusion. In particular, the angulations or orientations of PDL are critically important to transmit external stimuli and provide biomechanical adaptations for tooth-supporting functions. However, many studies still have demonstrated that optimal-biomechanical stimulations could re-make the configurations and orientations of PDL bundles with the low predictability in pre-clinical and clinical models. Here, we discussed the advanced technologies and geometric specifications for engineered PDL-guiding approaches spatiotemporally as 3D platforms.

Keyword

Periodontal tissue; Periodontal ligament; Biomaterials; Regenerative medicine; Tissue engineering

MeSH Terms

Biocompatible Materials
Connective Tissue
Dental Cementum
Mastication
Periodontal Ligament*
Regeneration*
Regenerative Medicine
Tissue Engineering
Biocompatible Materials