Korean J Health Promot.  2019 Dec;19(4):196-201. 10.15384/kjhp.2019.19.4.196.

The Relationship between Pulmonary Function and Serum Uric Acid Level in the Korean Population

  • 1Department of Senior Healthcare, General Graduate School, Eulji University, Seongnam, Korea.
  • 2Department of Biomedical Laboratory Science, College of Health Science, Eulji University, Seongnam, Korea. jsull@eulji.ac.kr


Forced vital capacity (FVC), forced expiratory volume in the first second (FEV₁), and the ratio of FEV₁ to FVC (FEV₁/FVC) are considered as the major spirometry parameters. Serum uric acid is associated with increased risk of gout and cardiovascular disease. We analyzed the relationship between pulmonary function and serum uric acid level in the Korean men and women.
This study was based on the data collected during the 2016 Korea National Health and Nutrition Examination Survey (KNHANES VII-1). A total of 3,411 adults were retrieved from KNHANES VII-1. Among 3,411 adults, 1,500 were men and 1,911 were women.
In this study, a significant negative correlation was observed between serum uric acid level and pulmonary function values only in females. Also, in the male non-smoker group, pulmonary function values were negatively associated with serum uric acid level (FVC %predicted, β=−0.014; FEV₁ %predicted, β=−0.015).
In this study, hyperuricemia was associated with the low lung function in males and females. In order to obtain an accurate assessment of the association between hyperuricemia and pulmonary function values, further prospective cohort study in the future is necessary.


Uric acid; Lung diseases; Hyperuricemia; Vital capacity; Forced expiratory volume

MeSH Terms

Cardiovascular Diseases
Cohort Studies
Forced Expiratory Volume
Lung Diseases
Nutrition Surveys
Prospective Studies
Uric Acid*
Vital Capacity
Uric Acid


1. Barreiro TJ, Perillo I. An approach to interpreting spirometry. Am Fam Physician. 2004; 69(5):1107–1114.
2. Villegas R, Xiang YB, Cai Q, Fazio S, Linton M, Li H, et al. Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese men. Metab Syndr Relat Disord. 2010; 8(3):263–270.
3. Nicks ME, O'Brien MM, Bowler RP. Plasma antioxidants are associated with impaired lung function and COPD exacerbations in smokers. COPD. 2011; 8(4):264–269.
4. Durmus Kocak N, Sasak G, Aka Akturk U, Akgun M, Boga S, Sengul A, et al. Serum uric acid levels and uric acid/creatinine ratios in stable chronic obstructive pulmonary disease (COPD) patients: are these parameters efficient predictors of patients at risk for exacerbation and/or severity of disease. Med Sci Monit. 2016; 22:4169–4176.
5. Aida Y, Shibata Y, Osaka D, Abe S, Inoue S, Fukuzaki K, et al. The relationship between serum uric acid and spirometric values in participants in a health check: the Takahata study. Int J Med Sci. 2011; 8(6):470–478.
6. Bardin T, Richette P. Definition of hyperuricemia and gouty conditions. Curr Opin Rheumatol. 2014; 26(2):186–191.
7. Mannino DM, Buist AS. Global burden of COPD: risk factors, prevalence, and future trends. Lancet. 2007; 370(9589):765–773.
8. B L, T W, Hn Z, Ww Y, Hp Y, Cx L, et al. The prevalence of hyperuricemia in China: a meta-analysis. BMC Public Health. 2011; 11:832.
9. Kim Y, Kang J, Kim GT. Prevalence of hyperuricemia and its associated factors in the general Korean population: an analysis of a population-based nationally representative sample. Clin Rheumatol. 2018; 37(9):2529–2538.
10. Gan WQ, Man SF, Sin DD. The interactions between cigarette smoking and reduced lung function on systemic inflammation. Chest. 2005; 127(2):558–564.
11. Burchfiel CM, Marcus EB, Curb JD, Maclean CJ, Vollmer WM, Johnson LR, et al. Effects of smoking and smoking cessation on longitudinal decline in pulmonary function. Am J Respir Crit Care Med. 1995; 151(6):1778–1785.
12. Shibata Y, Inoue S, Watanabe M. Impact of reduced pulmonary function in the Japanese general population: lessons from the Yamagata-Takahata study. Respir Investig. 2019; 57(3):220–226.
13. Fukuhara A, Saito J, Sato S, Saito K, Fukuhara N, Tanino Y, et al. The association between risk of airflow limitation and serum uric acid measured at medical health check-ups. Int J Chron Obstruct Pulmon Dis. 2017; 12:1213–1219.
14. Koran Centers for Disease Control and Prevention (KCDC). Korea National Health and Nutrition Examination Survey (KNHANES) [Internet]. Cheongju: KCDC;2018. Accessed Jul 27, 2018. Available from: https://knhanes.cdc.go.kr/knhanes/main.do.
15. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med. 1995; 152(3):1107–1136.
16. Choi JK, Paek D, Lee JO. Normal predictive values of spirometry in Korean population. Tuberc Respir Dis. 2005; 58(3):230–242.
17. Sarangi R, Varadhan N, Bahinipati J, Dhinakaran A, Anandaraj , Ravichandran K. Serum uric acid in chronic obstructive pulmonary disease: a hospital based case control study. J Clin Diagn Res. 2017; 11(9):BC09–BC13.
18. Song JU, Hwang J, Ahn JK. Serum uric acid is positively associated with pulmonary function in Korean health screening examinees. Mod Rheumatol. 2017; 27(6):1057–1065.
19. Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 2011; 63(10):3136–3141.
20. Marangella M. Uric acid elimination in the urine. Pathophysiological implications. Contrib Nephrol. 2005; 147:132–148.
21. Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA. Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2010; 62(2):170–180.
22. Kim JW, Kwak SG, Lee H, Kim SK, Choe JY, Park SH. Prevalence and incidence of gout in Korea: data from the national health claims database 2007-2015. Rheumatol Int. 2017; 37(9):1499–1506.
23. Yoo TW, Sung KC, Shin HS, Kim BJ, Kim BS, Kang JH, et al. Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Circ J. 2005; 69(8):928–933.
24. Sung KC, Suh JY, Kim BS, Kang JH, Kim H, Lee MH, et al. High sensitivity C-reactive protein as an independent risk factor for essential hypertension. Am J Hypertens. 2003; 16(6):429–433.
25. Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax. 2004; 59(7):574–580.
26. Garcia-Pachon E, Padilla-Navas I, Shum C. Serum uric acid to creatinine ratio in patients with chronic obstructive pulmonary disease. Lung. 2007; 185(1):21–24.
27. Zhang X, Liu L, Liang R, Jin S. Hyperuricemia is a biomarker of early mortality in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2015; 10:2519–2523.
28. Bartziokas K, Papaioannou AI, Loukides S, Papadopoulos A, Haniotou A, Papiris S, et al. Serum uric acid as a predictor of mortality and future exacerbations of COPD. Eur Respir J. 2014; 43(1):43–53.
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