Allergy Asthma Immunol Res.  2020 Mar;12(2):364-370. 10.4168/aair.2020.12.2.364.

Primary Nasal Epithelial Cells From Allergic and Non-allergic Individuals Show Comparable Barrier Function

  • 1Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
  • 2Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
  • 3NRC Institute of Immunology FMBA of Russia, Moscow, Russia.
  • 4Laboratory for Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia.


Previous reports suggested that ex vivo cultured primary nasal epithelial cells from allergic patients differ from those from non-allergic individuals by genuinely reduced barrier function. By contrast, we found that primary nasal epithelial cells from allergic and non-allergic individuals showed comparable barrier function and secretion of cytokines.


Respiratory epithelial barrier function; allergic rhinitis; allergen; immunoglobulin E; allergen-microarray; transepithelial resistance
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