Allergy Asthma Immunol Res.  2020 Mar;12(2):176-237. 10.4168/aair.2020.12.2.176.

Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis

Affiliations
  • 1Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 2Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 3Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
  • 4International Centre for Allergy Research, Nanjing Medical University, Nanjing, China.
  • 5Department of Otolaryngology, Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China.
  • 6Department of Otolaryngology, West China Hospital, Sichuan University, Chengdu, China.
  • 7Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. dr.luozhang@139.com, entzhou@263.net
  • 8Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.
  • 9Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • 10Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
  • 11Department of Otolaryngology Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • 12Otorhinolaryngology Hospital, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • 13Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, China.
  • 14Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • 15Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
  • 16Department of Otolaryngology Head and Neck Surgery, The Second Hospital, Shanxi Medical University, Taiyuan, China.
  • 17Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
  • 18Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, China.

Abstract

The current document is based on a consensus reached by a panel of experts from the Chinese Society of Allergy and the Chinese Society of Otorhinolaryngology-Head and Neck Surgery, Rhinology Group. Chronic rhinosinusitis (CRS) affects approximately 8% of Chinese adults. The inflammatory and remodeling mechanisms of CRS in the Chinese population differ from those observed in the populations of European descent. Recently, precision medicine has been used to treat inflammation by targeting key biomarkers that are involved in the process. However, there are no CRS guidelines or a consensus available from China that can be shared with the international academia. The guidelines presented in this paper cover the epidemiology, economic burden, genetics and epigenetics, mechanisms, phenotypes and endotypes, diagnosis and differential diagnosis, management, and the current status of CRS in China. These guidelines"”with a focus on China"”will improve the abilities of clinical and medical staff during the treatment of CRS. Additionally, they will help international agencies in improving the verification of CRS endotypes, mapping of eosinophilic shifts, the identification of suitable biomarkers for endotyping, and predicting responses to therapies. In conclusion, these guidelines will help select therapies, such as pharmacotherapy, surgical approaches and innovative biotherapeutics, which are tailored to each of the individual CRS endotypes.

Keyword

Chronic, sinusitis; China; guideline; inflammation; biomarkers; epigenesis; phenotype; endotypes; diagnosis; management

MeSH Terms

Adult
Asian Continental Ancestry Group*
Biomarkers
China
Consensus
Diagnosis
Diagnosis, Differential
Drug Therapy
Eosinophils
Epidemiology
Epigenomics
Genetics
Humans
Hypersensitivity*
Inflammation
International Agencies
Medical Staff
Neck*
Phenotype
Precision Medicine
Biomarkers
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