J Korean Med Sci.  2016 Sep;31(9):1499-1502. 10.3346/jkms.2016.31.9.1499.

Delayed Diagnosis of Falciparum Malaria with Acute Kidney Injury

• Choi IH
• Hwang PH
• Choi SI
• Lee DY
• Kim MS

• KMID: 2468286
• DOI: http://doi.org/10.3346/jkms.2016.31.9.1499

Abstract

Prompt malaria diagnosis is crucial so antimalarial drugs and supportive care can then be rapidly initiated. A 15-year-old boy who had traveled to Africa (South Africa, Kenya, and Nigeria between January 3 and 25, 2011) presented with fever persisting over 5 days, headache, diarrhea, and dysuria, approximately 17 days after his return from the journey. Urinalysis showed pyuria and hematuria. Blood examination showed hemolytic anemia, thrombocytopenia, disseminated intravascular coagulation, and hyperbilirubinemia. Plasmapheresis and hemodialysis were performed for 19 hospital days. Falciparum malaria was then confirmed by peripheral blood smear, and antimalarial medications were initiated. The patient's condition and laboratory results were quickly normalized. We report a case of severe acute renal failure associated with delayed diagnosis of falciparum malaria, and primary use of supportive treatment rather than antimalarial medicine. The present case suggests that early diagnosis and treatment is important because untreated tropical malaria can be associated with severe acute renal failure and fatality. Physicians must be alert for correct diagnosis and proper management of imported tropical malaria when patients have travel history of endemic areas.

Keyword

Plasmodium falciparum; Malaria; Diagnosis; Renal Failure; Dialysis, Plasmapheresis

MeSH Terms

Acute Kidney Injury/*complications
Adolescent
DNA, Protozoan/analysis
Delayed Diagnosis
Glomerular Filtration Rate
Humans
Malaria, Falciparum/complications/*diagnosis/parasitology
Male
Plasmodium falciparum/genetics/isolation & purification
Polymerase Chain Reaction
Renal Dialysis
DNA, Protozoan

Figure

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  Fig. 1 Peripheral blood smears. (A) On admission day. (B) On 10 hospital day. (C) On 19 hospital day. Arrows indicate RBCs with a ring.

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  Fig. 2 Clinical progression of fever, and glomerular filtration rate in the reported patient.

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