Investig Magn Reson Imaging.  2019 Dec;23(4):367-373. 10.13104/imri.2019.23.4.367.

Primary Pelvic Peritoneal Yolk Sac Tumor in the Post-Pubertal Female: a Case Report with Literature Review

Affiliations
  • 1Department of Radiology, Soonchunhyang University Seoul Hospital, Seoul, Korea. demian3923@naver.com
  • 2Department of Pathology, Soonchunhyang University Seoul Hospital, Seoul, Korea.
  • 3Department of Obstetrics and Gynecology, Soonchunhyang University Seoul Hospital, Seoul, Korea.

Abstract

Yolk sac tumors are rare malignant germ cell neoplasms that usually arise from the gonads. Extragonadal yolk sac tumors (EGYSTs) frequently occur in the mediastinum in post-pubertal females. EGYSTs in the pelvis are extremely rare, and to date, only thirteen cases have been reported in the English literature. Among them, the primary EGYST of the pelvic peritoneum in post-pubertal females has only been reported in ten cases. The present case describes a 26-year-old female diagnosed with primary peritoneal yolk sac tumor located in the rectouterine pouch. We report clinical and tumor imaging features, including ultrasound, computed tomography (CT), magnetic resonance images (MRI), positron emission tomography-computed tomography (PET-CT), and present a review of the literature.

Keyword

Primary peritoneal yolk sac tumor; Germ cell tumor; CT; MRI; PET-CT; AFP

MeSH Terms

Adult
Douglas' Pouch
Electrons
Endodermal Sinus Tumor*
Female*
Gonads
Humans
Magnetic Resonance Imaging
Mediastinum
Neoplasms, Germ Cell and Embryonal
Pelvis
Peritoneum
Ultrasonography
Yolk Sac*

Figure

  • Fig. 1 On transvaginal ultrasound, a 9.5 × 6.1 cm-sized, well-defined, solid mass with heterogeneous echogenicity and a small central anechoic component (white arrow) was seen in the pelvic cavity.

  • Fig. 2 Axial contrast-enhanced computed tomography scan revealed a 9.3 × 7.0 cm-sized predominantly solid mass in the rectouterine pouch with heterogeneous enhancement. The mass closely abutted the posterior aspect of the uterus (white solid arrow) and right adnexa (dashed white arrow).

  • Fig. 3 Dynamic contrast-enhanced pelvic magnetic resonance images showing the mass located in the cul-de-sac that appeared predominantly solid with intermediate-to-high signal intensity on a sagittal T2-weighted image (a). Note that both normal ovaries are observed as separate from the mass on a coronal T2-weighted image (b, white arrows). There is a central focal area of high signal intensity on both T1- and T2-weighted images with diffusion restriction (white arrowheads in a, c, d), suggesting hemorrhage.

  • Fig. 4 Avid uptake of the pelvic mass was noted on the 18F-fluorodeoxyglucose positron emission tomography-computed tomography scan (maximum standardized uptake value, SUVmax: 6.2).

  • Fig. 5 (a) On the histological examination, the mass was predominantly composed of a loose network of anastomosing channels or micro cysts consisting of tumor cells with varying amounts of clear or eosinophilic cytoplasm. Many Schiller-Duval bodies (black arrows) were present (Hematoxylin and Eosin staining, × 100). (b) The tumor cells were positive for alpha-fetoprotein (AFP, × 100).


Reference

1. Gilbert KL, Bergman S, Dodd LG, Volmar KE, Creager AJ. Cytomorphology of yolk sac tumor of the liver in fine-needle aspiration: a pediatric case. Diagn Cytopathol. 2006; 34:421–423.
2. Huntington RW Jr, Bullock WK. Yolk sac tumors of extragonadal origin. Cancer. 1970; 25:1368–1376.
3. Thiele J, Castro S, Lee KD. Extragonadal endodermal sinus tumor (yolk sac tumor) of the pelvis. Cancer. 1971; 27:391–396.
4. Clement PB, Young RH, Scully RE. Extraovarian pelvic yolk sac tumors. Cancer. 1988; 62:620–626.
5. Dede M, Pabuccu R, Yagci G, Yenen MC, Goktolga U, Gunhan O. Extragonadal yolk sac tumor in pelvic localization. A case report and literature review. Gynecol Oncol. 2004; 92:989–999.
6. Tseng MJ, Jung SM. Primary extra-gonadal yolk-sac tumour of pelvis with unusual presentation. Lancet Oncol. 2007; 8:179–180.
7. Pasternack T, Shaco-Levy R, Wiznitzer A, Piura B. Extraovarian pelvic yolk sac tumor: case report and review of published work. J Obstet Gynaecol Res. 2008; 34:739–744.
8. Baba T, Su S, Umeoka S, et al. Advanced extragonadal yolk sac tumor serially followed up with (18)F-fluorodexyglucose-positoron emission tomography and computerized tomography and serum alpha-fetoprotein. J Obstet Gynaecol Res. 2012; 38:605–609.
9. Rudaitis V, Mickys U, Katinaite J, Dulko J. Successful treatment of advanced stage yolk sac tumour of extragonadal origin: a case report and review of literature. Acta Med Litu. 2016; 23:110–116.
10. Garnick MB, Canellos GP, Richie JP. Treatment and surgical staging of testicular and primary extragonadal germ cell cancer. JAMA. 1983; 250:1733–1741.
11. McKenney JK, Heerema-McKenney A, Rouse RV. Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations. Adv Anat Pathol. 2007; 14:69–92.
12. Shaaban AM, Rezvani M, Elsayes KM, et al. Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features. Radiographics. 2014; 34:777–801.
13. Ravishankar S, Malpica A, Ramalingam P, Euscher ED. Yolk sac tumor in extragonadal pelvic sites: still a diagnostic challenge. Am J Surg Pathol. 2017; 41:1–11.
14. Wang M, Jiang S, Zhang Y, et al. The application of 18F-FDG PET/CT in ovarian immature teratomas when pathological examination results contradict clinical observations: a case report. Medicine (Baltimore). 2017; 96:e9171.
15. Takehara K, Konishi H, Kojima A, et al. SUV max of FDG-PET/CT as a prognostic factor in ovarian clear cell adenocarcinoma. J Clin Oncol. 2014; 32:e16509.
Full Text Links
  • IMRI
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2023 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr