Infect Chemother.  2019 Dec;51(4):405-413. 10.3947/ic.2019.51.4.405.

Hemorrhagic Fever with Renal Syndrome

• Noh JY
• Jung J
• Song JW

• KMID: 2466474
• DOI: http://doi.org/10.3947/ic.2019.51.4.405

Abstract

In Korea, hemorrhagic fever with renal syndrome (HFRS) was first reported in a United Nations (UN) soldier stationed in the central front, also known as the "Iron Triangle". In 1976, professor Ho Wang Lee discovered an antigen in the lung and kidney tissues of Apodemus agrarius. In 1980, this novel virus was named Hantaan virus after the Hantaan river. The Old World Hantaviruses, which are usually found in East Asia and Europe, are generally transmitted to humans via the respiratory pathway during dry seasons, usually in late spring and fall. Currently, 300 - 600 cases per year are reported in Korea with a mortality rate of 1 - 2%. The typical clinical course of HFRS is classified into five phases: febrile, hypotensive, oliguric, diuretic, and convalescent. And treatment for HFRS is mostly conservative. A vaccine for the Hantaan virus was developed in 1988 and marketed in 1990. Because HFRS outbreaks mostly occur in regions near the truce line in Korea, vaccination is virtually the only protection against the virus among military personnel working in such regions and local residents. Therefore, proving the effectiveness of the HFRS vaccine and devising efficient vaccination plans have been considered a major task for Korea's health authorities.

Keyword

Family hantaviridae; Hemorrhagic fever with renal syndrome; Hantavirus; Epidemiology

MeSH Terms

Animals
Disease Outbreaks
Epidemiology
Europe
Far East
Hantaan virus
Hantavirus
Hemorrhagic Fever with Renal Syndrome*
Humans
Kidney
Korea
Lung
Military Personnel
Mortality
Murinae
Rivers
Seasons
United Nations
Vaccination

Figure

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  Figure 1 Apodemus agrarius, the host for Hantaan virus.

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  Figure 2 Regions affected by the hemorrhagic fever with renal syndrome epidemic, including Hantaan River.

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  Figure 3 Incidence of hemorrhagic fever with renal syndrome in Korea since 1951.

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  Figure 4 Distribution of Hantavax™ and changes in the incidence of HFRS in the Korea Armed Forces.

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  Fig. 5 Korea military training ground with restricted entry.

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