Pediatr Infect Vaccine.  2019 Dec;26(3):188-193. 10.14776/piv.2019.26.e19.

Cerebral Venous Sinus Thrombosis with Meningitis and Septicemia due to Haemophilus influenzae Type f in an Immunocompetent Child

Affiliations
  • 1Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, the Republic of Korea. yuheejoon@hallym.or.kr

Abstract

Since the implementation of conjugate Haemophilus influenzae serotype b (Hib) vaccine, the rate of infections caused by Hib has dramatically decreased, and the proportion of infections caused by non-type b H. influenzae has increased. Cerebral venous sinus thrombosis (CVST) is rare; however, it should be considered as a potential complication of bacterial meningitis. Herein, we report about a child who developed CVST after being diagnosed with H. influenzae serotype f meningitis.

Keyword

Meningitis, haemophilus; Sinus thrombosis, intracranial; Central Nervous system infections; Cerebrospinal fluid; Bacteremia

MeSH Terms

Bacteremia
Central Nervous System Infections
Cerebrospinal Fluid
Child*
Haemophilus influenzae type b
Haemophilus influenzae*
Haemophilus*
Humans
Influenza, Human
Meningitis*
Meningitis, Bacterial
Meningitis, Haemophilus
Sepsis*
Serogroup
Sinus Thrombosis, Intracranial*

Figure

  • Fig. 1 Non-contrast-enhanced computed tomography performed on the 1st hospital day showed a high-density lesion noted in right transverse-sigmoid sinus area (arrow) (A). Brain magnetic resonance images were taken on the 5th hospital day (B-D). Distended right side transverse-sigmoid sinus was hyperintense on axial contrast-enhanced T1-weighted image (B) and hypointense on susceptibility-weighted image (C). Right side transverse and sigmoid sinus obstruction is seen on venography (D).

  • Fig. 2 The follow-up brain magnetic resonance images performed 2 months after the initial study. The aforementioned hyperintense lesion appears to have resolved on contrast-enhanced T1-weighted image (A) and the hypointense lesion has almost disappeared on susceptibility-weighted image (B). Recanalization of thrombosis was seen in right side transverse and sigmoid sinus on venography (C).


Reference

1. Urwin G, Krohn JA, Deaver-Robinson K, Wenger JD, Farley MM. The Haemophilus influenzae Study Group. Invasive disease due to Haemophilus influenzae serotype f: clinical and epidemiologic characteristics in the H. influenzae serotype b vaccine era. Clin Infect Dis. 1996; 22:1069–1076.
Article
2. Campos J, Román F, Pérez-Vázquez M, Aracil B, Oteo J, Cercenado E, et al. Antibiotic resistance and clinical significance of Haemophilus influenzae type f. J Antimicrob Chemother. 2003; 52:961–966.
Article
3. Ronit A, Berg RM, Bruunsgaard H, Plovsing RR. Haemophilus influenzae type f meningitis in a previously healthy boy. BMJ Case Rep. 2013; 2013:bcr2013008854.
4. Pincus DR, Robson JM. Meningitis due to Haemophilus influenzae type f. J Paediatr Child Health. 1998; 34:95–96.
5. Hedlund GL. Cerebral sinovenous thrombosis in pediatric practice. Pediatr Radiol. 2013; 43:173–188.
Article
6. Bozzola E, Bozzola M, Colafati GS, Calcaterra V, Vittucci A, Luciani M, et al. Multiple cerebral sinus thromboses complicating meningococcal meningitis: a pediatric case report. BMC Pediatr. 2014; 14:147.
Article
7. Ünver O, Ekinci G, Kutlubay BI, Gülten T, Güneş S, Hacıfazlıoğlu NE, et al. Evaluation of cases with cerebral thrombosis in children. Turk Pediatri Ars. 2016; 51:87–93.
Article
8. Choe YJ, Han OP, Cho H, Bae GR, Chun BC, Kim JH, et al. Prioritization of the introduction of new vaccines to the national immunization program in the Republic of Korea. Vaccine. 2014; 32:6049–6053.
Article
9. Cho HK, Lee H, Kang JH, Kim KN, Kim DS, Kim YK, et al. The causative organisms of bacterial meningitis in Korean children in 1996–2005. J Korean Med Sci. 2010; 25:895–899.
Article
10. Lee JH, Cho HK, Kim KH, Kim CH, Kim DS, Kim KN, et al. Etiology of invasive bacterial infections in immunocompetent children in Korea (1996–2005): a retrospective multicenter study. J Korean Med Sci. 2011; 26:174–183.
Article
11. Rhie K, Choi EH, Cho EY, Lee J, Kang JH, Kim DS, et al. Etiology of invasive bacterial infections in immunocompetent children in Korea (2006–2010): a retrospective multicenter study. J Korean Med Sci. 2018; 33:e45.
Article
12. Chirakkara SKP, Bakhsh ARA, Pariyadath AK, Rathinavelu B. Cerebral venous sinus thrombosis in a patient with meningococcal meningitis. Oman Med J. 2018; 33:61–64.
Article
13. Amara U, Rittirsch D, Flierl M, Bruckner U, Klos A, Gebhard F, et al. Interaction between the coagulation and complement system. Adv Exp Med Biol. 2008; 632:68–76.
Article
14. Cho JY, Han BM, Kim HM, Lim BK, Cha BH. A case of intracerebral thrombosis and cortical hemorrhage complicated by Streptococcus pneumoniae meningitis. J Korean Child Neurol Soc. 2003; 11:362–366.
15. Dhamija RM, Bansal J. Bacterial meningitis (meningoencephalitis): a review. J Indian Acad Clin Med. 2006; 7:225–235.
16. Ferro JM, Canhão P. Cerebral venous sinus thrombosis: update on diagnosis and management. Curr Cardiol Rep. 2014; 16:523.
Article
17. Syed NB, Marktanner R, Gharaibeh D. Warfarin-induced pseudo-allergy. J Hematol (Brossard). 2014; 3:116–117.
Article
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