Korean J Radiol.  2016 Dec;17(6):827-845. 10.3348/kjr.2016.17.6.827.

Structural MR Imaging in the Diagnosis of Alzheimer's Disease and Other Neurodegenerative Dementia: Current Imaging Approach and Future Perspectives

  • 1Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 05030, Korea. mdmoonwj@kuh.ac.kr


With the rise of aging population, clinical concern and research attention has shifted towards neuroimaging of dementia. The advent of 3T, magnetic resonance imaging (MRI) has permitted the anatomical imaging of neurodegenerative disease, specifically dementia, with improved resolution. Furthermore, more powerful techniques such as diffusion tensor imaging, quantitative susceptibility mapping, and magnetic transfer imaging have successfully emerged for the detection of micro-structural abnormalities. In the present review article, we provide a brief overview of Alzheimer's disease and explore recent neuroimaging developments in the field of dementia with an emphasis on structural MR imaging in order to propose a simple and easily applicable systematic approach to the imaging diagnosis of dementia.


Dementia; Alzheimer's disease; Quantitative imaging; Magnetic resonance imaging; Diagnosis

MeSH Terms

Alzheimer Disease/*diagnosis/diagnostic imaging
Atrophy/diagnosis/diagnostic imaging
Brain/diagnostic imaging/pathology
Dementia/*diagnosis/diagnostic imaging
Diffusion Tensor Imaging
*Magnetic Resonance Imaging
White Matter/diagnostic imaging/pathology
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