J Korean Ophthalmol Soc.  2019 Dec;60(12):1369-1373. 10.3341/jkos.2019.60.12.1369.

Anti-Vascular Endothelial Growth Factor Therapy for Choroidal Neovascularization Secondary to Optic Nerve Head Drusen

• Park KH

• KMID: 2466198
• DOI: http://doi.org/10.3341/jkos.2019.60.12.1369

Abstract

PURPOSE
To describe a patient with optic nerve head drusen who showed improved retinal hemorrhage and visual acuity following intravitreal anti-vascular endothelial growth factor (bevacizumab) injection.
CASE SUMMARY
A 53-year-old woman with no underlying disease presented with sudden vision loss in her left eye. Her best-corrected visual acuity was 1.0 in the right eye and 0.8 in the left eye; the intraocular pressure was 15 mmHg in both eyes. Anterior segment examination revealed no abnormal findings. Fundus examination showed subretinal hemorrhage and serous retinal detachment in the left eye. Fluorescein angiography and indocyanine green fundus examination revealed hyperfluorescence near the optic disc. The patient was diagnosed with choroidal neovascularization of the left eye secondary to optic nerve head drusen; intravitreal bevacizumab injection was then performed. Three weeks later, the patient showed improved retinal hemorrhage.
CONCLUSIONS
Intravitreal anti-vascular endothelial growth factor injection may be an effective treatment for choroidal neovascularization associated with optic nerve head drusen.

Keyword

Anti-vascular endothelial growth factor; Bevacizumab; Choroidal neovascularization; Intravitreal injection; Optic nerve head drusen

MeSH Terms

Bevacizumab
Choroid*
Choroidal Neovascularization*
Endothelial Growth Factors*
Female
Fluorescein Angiography
Hemorrhage
Humans
Indocyanine Green
Intraocular Pressure
Intravitreal Injections
Middle Aged
Optic Disk*
Optic Nerve*
Retinal Detachment
Retinal Hemorrhage
Visual Acuity
Bevacizumab
Endothelial Growth Factors
Indocyanine Green

Figure

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  Figure 1 Visual field tests of both eyes at the first visit.

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  Figure 2 Fundus photography of both eyes. (A) Pre-treatment and (B) post-treatment fundus photography at 3 weeks after intravitrealbevacizumab injection.

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  Figure 3 Optical coherence tomography(OCT) and retinal angiograms of the lefteye. (A) A hyperreflective subretinal masslikelesion (white arrow) is buried at opticdisc and subretinal fluid extended fromthe optic nerve head to the macula andpigment epithelial detachment (blue arrow)is observed on OCT. (B) Fluoresceinand Indocyanine green angiogram revealedround small hyperfluorescencewithin the hypofluorescence area of subretinalhemorrhage.

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