J Pathol Transl Med.  2019 Mar;53(2):142-144. 10.4132/jptm.2018.05.25.

Crystal-Storing Histiocytosis with Plasma Cell Neoplasm in the Setting of Chronic Carbamazepine Exposure

Affiliations
  • 1Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT, USA. WooCheal.Cho@hhchealth.org

Abstract

No abstract available.


MeSH Terms

Carbamazepine*
Histiocytosis*
Neoplasms, Plasma Cell*
Plasma Cells*
Plasma*
Carbamazepine

Figure

  • Fig. 1. Histologic findings of bone marrow biopsy. (A, B) Bone marrow biopsy showed infiltration and near-total replacement by cells filled with eosinophilic crystalloid material. The neoplastic cells were CD138-positive (C), kappa-restricted plasma cells, while the remainder of the cell population were histiocytes highlighted by CD68 (D) and CD163 (not shown). (E) Kappa expression was also noted within the histiocytes.


Reference

1. Kapadia SB, Enzinger FM, Heffner DK, Hyams VJ, Frizzera G. Crystal-storing histiocytosis associated with lymphoplasmacytic neoplasms: report of three cases mimicking adult rhabdomyoma. Am J Surg Pathol. 1993; 17:461–7.
2. Lebeau A, Zeindl-Eberhart E, Müller EC, et al. Generalized crystalstoring histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature. Blood. 2002; 100:1817–27.
Article
3. Jones D, Bhatia VK, Krausz T, Pinkus GS. Crystal-storing histiocytosis: a disorder occurring in plasmacytic tumors expressing immunoglobulin kappa light chain. Hum Pathol. 1999; 30:1441–8.
4. Sukpanichnant S, Hargrove NS, Kachintorn U, et al. Clofazimineinduced crystal-storing histiocytosis producing chronic abdominal pain in a leprosy patient. Am J Surg Pathol. 2000; 24:129–35.
Article
5. Dogan S, Barnes L, Cruz-Vetrano WP. Crystal-storing histiocytosis: report of a case, review of the literature (80 cases) and a proposed classification. Head Neck Pathol. 2012; 6:111–20.
Article
6. Olsen JH, Schulgen G, Boice JD Jr, et al. Antiepileptic treatment and risk for hepatobiliary cancer and malignant lymphoma. Cancer Res. 1995; 55:294–7.
7. Gado K, Domjan G, Hegyesi H, Falus A. Role of INTERLEUKIN-6 in the pathogenesis of multiple myeloma. Cell Biol Int. 2000; 24:195–209.
8. Verrotti A, Basciani F, Trotta D, Greco R, Morgese G, Chiarelli F. Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte chemoattractant protein-1. Clin Exp Med. 2001; 1:133–6.
Article
9. Moreno-Ancillo A, Cosmes Martin PM, Dominguez-Noche C, et al. Carbamazepine induced transient monoclonal gammopathy and immunodeficiency. Allergol Immunopathol (Madr). 2004; 32:86–8.
Article
10. Günaldı M, Paydas¸ S, Usul Afs¸ar C, Bozkurt Duman B, Erçolak V, Haksöyler V. Carbamazepine and multiple myeloma: possible interaction. Turk J Haematol. 2013; 30:83–4.
Article
Full Text Links
  • JPTM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr