J Pathol Transl Med.  2019 Nov;53(6):399-402. 10.4132/jptm.2019.08.05.

Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy

Affiliations
  • 1Department of Pathology, Chungnam National University School of Medicine, Daejeon, Republic of Korea. mkyeo83@gmail.com
  • 2Department of Nephrology, Chungnam National University School of Medicine, Daejeon, Republic of Korea.

Abstract

Anti-glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of IgG along the GBM. In a limited number of cases, glomerular immune complexes have been identified in anti-GBM nephritis. A 38-year-old female presented azotemia, hematuria, and proteinuria without any pulmonary symptoms. A renal biopsy showed crescentic GN with linear IgG deposition along the GBM and mesangial IgA deposition. The patient was diagnosed as concurrent anti-GBM nephritis and IgA nephropathy. Therapies with pulse methylprednisolone and cyclophosphamide administration were effective. Concurrent cases of both anti-GBM nephritis and IgA nephropathy are rare among cases of anti-GBM diseases with deposition of immune complexes. This rare case of concurrent anti-GBM nephritis and IgA nephropathy with literature review is noteworthy.

Keyword

Anti-glomerular basement membrane disease; Immunoglobulin A; Crescentic glomerulonephritis

MeSH Terms

Adult
Anti-Glomerular Basement Membrane Disease
Antibodies
Antigen-Antibody Complex
Azotemia
Basement Membrane*
Biopsy
Cyclophosphamide
Female
Glomerulonephritis
Glomerulonephritis, IGA*
Hematuria
Humans
Immunoglobulin A*
Immunoglobulin G
Methylprednisolone
Nephritis*
Proteinuria
Antibodies
Antigen-Antibody Complex
Cyclophosphamide
Immunoglobulin A
Immunoglobulin G
Methylprednisolone
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