Child Kidney Dis.
2019 Oct;23(2):86-92. 10.3339/jkspn.2019.23.2.86.
Genetic Basis of Steroid Resistant Nephrotic Syndrome
- Affiliations
-
- 1Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea. eujinpark@hallym.or.kr
- KMID: 2464932
- DOI: http://doi.org/10.3339/jkspn.2019.23.2.86
Abstract
- Steroid-resistant nephrotic syndrome (SRNS) has long been a challenge for clinicians due to its poor responsiveness to immunosuppressants, and rapid progression to end-stage renal disease. Identifying a monogenic cause for SRNS may lead to a better understanding of podocyte structure and function in the glomerular filtration barrier. This review focuses on genes associated with slit diaphragm, actin cytoskeleton, transcription factors, nucleus, glomerular basement membrane, mitochondria, and other proteins that affect podocyte biology.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Genetics of hereditary nephrotic syndrome: a clinical review
- Levamisole-Induced Reversible Agranulocytosis in Children with Steroid Dependent Nephrotic Syndrome
- Can We Predict How Often Nephrotic Syndrome will Relapse into the Patients?
- A Case of Cerebral Infarction due to Thrombosis Associated with Focal Segmental Glomerulosclerosis and Steroid Resistant Nephrotic Syndrome
- Genetic tests in children with steroid-resistant nephrotic syndrome
