Clin Psychopharmacol Neurosci.  2019 Nov;17(4):509-516. 10.9758/cpn.2019.17.4.509.

Altered Auditory P300 Performance in Parents with Attention Deficit Hyperactivity Disorder Offspring

Affiliations
  • 1Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. ykyang@mail.ncku.edu.tw
  • 2Department of Educational Psychiatry & Counseling, National Pingtung University, Pingtung, Taiwan.
  • 3Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • 4Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan.

Abstract

OBJECTIVE: Altered event-related potential (ERP) performances have been noted in attention deficit hyperactivity disorder (ADHD) patients and reflect neurocognitive dysfunction. Whether these ERP alterations and correlated dysfunctions exist in healthy parents with ADHD offspring is worth exploring.
METHODS
Thirteen healthy parents with ADHD offspring and thirteen healthy controls matched for age, sex and years of education were recruited. The auditory oddball paradigm was used to evaluate the P300 wave complex of the ERP, and the Wechsler Adult Intelligence Scale-Revised, Wisconsin Card Sorting Test, and continuous performance test were used to measure neurocognitive performance.
RESULTS
Healthy parents with ADHD offspring had significantly longer auditory P300 latency at Fz than control group. However, no significant differences were found in cognitive performance.
CONCLUSION
The presence of a subtle alteration in electro-neurophysiological activity without explicit neurocognitive dysfunction suggests potential candidate of biological marker for parents with ADHD offspring.

Keyword

Attention deficit disorder with hyperactivity; Cognition; Evoked potentials; P300; Parents
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