Tissue Eng Regen Med.  2019 Oct;16(5):433-442. 10.1007/s13770-019-00219-6.

Targeted Near-Infrared Fluorescence Imaging for Regenerative Medicine

Affiliations
  • 1Department of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. hchoi12@mgh.harvard.edu
  • 2Gimhae-Harvard Bioimaging Center, Gimhae Industry Promotion and Biomedical Foundation, 80-16 Golden rootro, Juchon-myeon, Gimhae 50969, Republic of Korea.

Abstract

BACKGROUND
Advances in tissue engineering and regenerative medicine over the last three decades have made great progress in the development of diagnostic and therapeutic methodologies for damaged tissues. However, regenerative medicine is still not the first line of treatment for patients due to limited understanding of the tissue regeneration process. Therefore, it is prerequisite to develop molecular imaging strategies combined with appropriate contrast agents to validate the therapeutic progress of damaged tissues.
METHODS
The goal of this review is to discuss the progress in the development of near-infrared (NIR) contrast agents and their biomedical applications for labeling cells and scaffolds, as well as monitoring the treatment progress of native tissue in living organisms. We also discuss the design consideration of NIR contrast agents for tissue engineering and regenerative medicine in terms of their physicochemical and optical properties.
RESULTS
The use of NIR imaging system and targeted contrast agents can provide high-resolution and high sensitivity imaging to track/monitor the in vivo fate of administered cells, the degradation rate of implanted scaffolds, and the tissue growth and integration of surrounding cells during the therapeutic period.
CONCLUSION
NIR fluorescence imaging techniques combined with targeted contrast agents can play a significant role in regenerative medicine by monitoring the therapeutic efficacy of implanted cells and scaffolds which would enhance the development of cell therapies and promote their successful clinical translations.

Keyword

Regenerative medicine; Molecular imaging; Near-infrared imaging; Contrast agent

MeSH Terms

Contrast Media
Fluorescence*
Humans
Molecular Imaging
Optical Imaging*
Regeneration
Regenerative Medicine*
Tissue Engineering
Translations
Contrast Media
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