J Korean Orthop Assoc.  1972 Sep;7(3):365-390. 10.4055/jkoa.1972.7.3.365.

Experimental Study on the Transplantation of Articular Cartilage

• Park BM

• KMID: 2463905
• DOI: http://doi.org/10.4055/jkoa.1972.7.3.365

Abstract

Of great interest in modern medicine is the subject of transplantation in the living body, concerned fundamentally with a shift from any damaged tissue or organ to a new one which will continue to live and function in a healthy manner. Much work and constant effort is in progress in this field and many accounts have been reported concerning attempts to solve this problem. Bone grafting, for example, has been highly successful, and now is widely used in orthopedic procedures, with good results. However, the transplantation of articular cartilage has not yet been improved to the point to warrant full-scale clinical application, although reports have appeared occasionally since the partial success achieved in man by Lexer (1908) and in animals by Judet (1908), and concerted efforts are at present being made to diecover a successful technique. Medawar (1948) reported that the failure of tissue homografte to "take" is known to be attributable to the active immune response called forth in the host by incompatibility antigens present in the cells of the grafted tissue. Bacsich and Wyburn (1947) concluded that the special behavior of these grafts is usually ascribed to the avascular nature of cartilage, the cells of which are separated from those of the host by a matrix which acts as a physical barrier and which may, in addition, have a specific protective capacity.(Continued....)

MeSH Terms

Allografts
Animals
Architectural Accessibility
Bone Transplantation
Cartilage
Cartilage, Articular*
History, Modern 1601-
Immunity, Active
Orthopedic Procedures
Transplants