Obstet Gynecol Sci.  2019 Nov;62(6):474-477. 10.5468/ogs.2019.62.6.474.

A rare case of gastric-type mucinous adenocarcinoma in a woman with Peutz-Jeghers syndrome

  • 1Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, College of Medicine, Dankook University, Seoul, Korea.
  • 2Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seoul, Korea.
  • 3Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Korea. joyfulplace@hanmail.net
  • 4Department of Obstetrics and Gynecology, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.
  • 5CHA Gangnam Medical Center, CHA University, Seoul, Korea.
  • 6Department of Pathology, Cheil General Hospital & Women's Healthcare Center, College of Medicine, Dankook University, Seoul, Korea.


Adenocarcinoma of the cervix is less common than squamous cell carcinoma. Minimal deviation adenocarcinoma (adenoma malignum) is considered an extremely well-differentiated variant of GAS. An association exists between GAS and Peutz-Jeghers syndrome, which is a rare autosomal dominant disorder characterized by mucocutaneous pigmentation and multiple hamartomatous polyps in the gastrointestinal tracts. The incidence of GAS in patients with Peutz-Jeghers syndrome is estimated to be 11-17%. We present a rare case of adenoma malignum, diagnosed using colposcopic biopsy in a woman with Peutz-Jeghers syndrome, which was histopathologically confirmed to be GAS after surgery.


Adenocarcinoma; Uterine cervical neoplasms; Peutz-Jeghers syndrome

MeSH Terms

Adenocarcinoma, Mucinous*
Carcinoma, Squamous Cell
Cervix Uteri
Gastrointestinal Tract
Peutz-Jeghers Syndrome*
Uterine Cervical Neoplasms


  • Fig. 1 (A) The cervix on colposcopy. (B, C) Pelvic magnetic resonance image showing an enlargement of the cervix with multiple cystic lesions (arrow). The cervical parametrium is intact.

  • Fig. 2 Histopathological results of colposcopic biopsy (A, B) and cervical conization (C-E). (A) The tumor consists of a mucinous epithelium infiltrating the cervical wall with little or no stromal reaction (original magnification ×4). (B) Cells lining these malignant glands have abundant clear cytoplasm and slightly enlarged nuclei with small nucleoli. Mitotic figures are rarely present (original magnification ×20). (C) Mucinous carcinoma of the gastric type with a more poorly differentiated component (original magnification ×20). (D) Immunohistochemical staining is positive for MUC6, a marker of pyloric gland mucin. (E) Immunohistochemical staining is focal positive but block pattern negative for p16.


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