J Korean Orthop Assoc.  2019 Oct;54(5):440-446. 10.4055/jkoa.2019.54.5.440.

Myxoid Liposarcoma: A Single Institute Experience

Affiliations
  • 1Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea. wssongmd@gmail.com
  • 2Department of Pathology, Korea Cancer Center Hospital, Seoul, Korea.

Abstract

PURPOSE
This study assessed the treatment outcomes of myxoid liposarcoma in the extremities and investigate the prognostic factors.
MATERIALS AND METHODS
A total of 91 patients with myxoid liposarcoma (83 primary, 8 recurrent) between 2001 and 2015 were reviewed retrospectively. The local recurrence and metastasis after treatment were examined. The survival rates and prognostic factors affecting the survival were investigated. The mean follow-up was 84 months (range, 5–196 months).
RESULTS
The overall survival rates at 5-yr and 10-yr were 82% and 74%, respectively. The tumor size (p=0.04), round cell component (p<0.0001), grade (p=0.0002), and local recurrence (p=0.006) affected survival in primary patients. Extrapulmonary metastases were observed in 75.0% (18/24) of metastatic patients and the mean post metastasis survival was 26 months (range, 2–72 months).
CONCLUSION
Myxoid liposarcoma developed mainly at the lower extremities. The tumor size, grade, component of round cells, and local recurrence were associated with the prognosis. The unique feature of extrapulmonary metastasis in myxoid liposarcoma should be noted in the treatment and follow-up.

Keyword

liposarcoma; myxoid liposarcoma; prognosis
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