Clin Nutr Res.  2019 Oct;8(4):318-328. 10.7762/cnr.2019.8.4.318.

Effects of Resistant Starch Supplementation on Glucose Metabolism, Lipid Profile, Lipid Peroxidation Marker, and Oxidative Stress in Overweight and Obese Adults: Randomized, Double-Blind, Crossover Trial

• Eshghi F
• Bakhshimoghaddam F
• Rasmi Y
• Alizadeh M

• KMID: 2461099
• DOI: http://doi.org/10.7762/cnr.2019.8.4.318

Abstract

Obesity is a substantial public health challenge across the globe. The use of resistant starch has been proposed as a probable management strategy for complications of obesity. We investigated the effects of resistant starch intake on lipid profiles, glucose metabolism, antioxidant status, lipid peroxidation marker, blood pressure, and anthropometric variables in subjects with overweight or obesity. In this 12-week, randomized, double-blind, placebo-controlled, 2 × 2 crossover trial, 21 Participants (mean age, 35 ± 7.0 years; body mass index, 32.4 ± 3.5 kg/m²) were given 13.5 g Hi-Maize 260 or placebo daily for 4 weeks, separated by a 4-week washout period. Changes in total antioxidant status (p = 0.04) and serum concentrations of insulin in 52.4% participants with insulin levels above 16 µIU/mL at the baseline (p = 0.04) were significantly different in the three phases. In addition, the mean of serum high-density lipoprotein cholesterol after the intervention was significantly higher than after baseline value (p = 0.04). We found no significant differences in serum concentrations of total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, fasting blood sugar, insulin, homeostatic model assessment of insulin resistance, quantitative insulin sensitivity check index, superoxide dismutase activity, malondialdehyde, blood pressure, and anthropometric variables in the three phases of baseline, after intervention with resistant starch and after placebo. Resistant starch consumption improved serum insulin concentrations, lipid profiles, and antioxidant status in subjects with overweight or obesity. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01992783

Keyword

Dietary fiber; Insulin resistance; Superoxide dismutase; Malondialdehyde; Overweight; Obesity

MeSH Terms

Adult*
Blood Glucose
Blood Pressure
Body Mass Index
Cholesterol
Dietary Fiber
Fasting
Glucose*
Humans
Insulin
Insulin Resistance
Lipid Metabolism*
Lipid Peroxidation*
Lipoproteins
Malondialdehyde
Metabolism*
Obesity
Overweight*
Oxidative Stress*
Public Health
Starch*
Superoxide Dismutase
Triglycerides
Blood Glucose
Cholesterol
Glucose
Insulin
Lipoproteins
Malondialdehyde
Starch
Superoxide Dismutase
Triglycerides

Figure

• 

  Figure 1 CONSORT diagram showing the flow of participant eligibility, screening, randomization, and follow-up through each stage of the randomized crossover trial.

• 

  Figure 2 Changes in TAS (A) and serum concentration of insulin in 52.4% participants with insulin levels above median (16 µIU/mL) at the baseline (B) in overweight or obesity subjects in the three phases of baseline, after intervention with resistant starch and after placebo for 12 weeks. Values are means ± standard deviations. On the basis of general linear model analysis of variance for repeated measurements there were significant differences in the three phases (p = 0.04). TAS, total antioxidant status.

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