Cancer Res Treat.  2019 Oct;51(4):1400-1410. 10.4143/crt.2018.704.

Report of the Korean Association of Lung Cancer Registry (KALC-R), 2014

Affiliations
  • 1Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 2Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 3Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.
  • 4Department of Thoracic & Cardiovascular Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
  • 5Center for Lung Cancer, National Cancer Center, Goyang, Korea.
  • 6Division of Pulmonology, Department of Internal Medicine, Chungnam National University, Daejeon, Korea.
  • 7Department of Medicine, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea.
  • 8Division of Pulmonology, Department of Internal Medicine, The Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 9Department of Cardiothoracic Surgery, Pusan National University Hospital, Busan, Korea.
  • 10Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.
  • 11Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea.
  • 12Cancer Registration and Statistics Branch, National Cancer Center, Goyang, Korea.
  • 13Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea. kyc0923@jnu.ac.kr
  • 14Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Abstract

PURPOSE
The aim of this study was to investigate epidemiology, clinical characteristics and sex differences of patients with lung cancer using nationwide registry in Korea.
MATERIALS AND METHODS
The Korean Association for Lung Cancer developed a registry in cooperation with the Korean Central Cancer Registry, and surveyed about 10% of lung cancer cases. For this first survey of cases diagnosed in 2014, cases were selected through a systematic sampling method.
RESULTS
Total 2,621 lung cancer patients were surveyed, and the median patient age was 70 years. During the study period, adenocarcinoma was the most frequent histologic type, the proportion of female patients was 28.4%, and women had a better prognosis (median survival, not reached vs. 13 months; p<0.001) than did men for non-small cell lung cancer. The proportion of never-smokers was 36.4%, and never-smoking was more prevalent in women than in men (87.5 vs. 16.0%, p<0.001). Epidermal growth factor receptor (EGFR) mutations were found in 36.8% of stage IV adenocarcinoma patients, and higher in female compared to male patients (51.2 vs. 26.6%, p<0.001). In addition, patients with EGFR mutation showed better survival (median survival, 18 vs. 8 months; p<0.001) than patients without EGFR mutation in these patients.
CONCLUSION
This is the first survey to gather unbiased nationwide lung cancer statistics in Korea. More than one-third of lung cancer patients had no smoking history. Female had a high proportion of non-smoker, more adenocarcinoma with EGFR mutation and generally better prognosis than male.

Keyword

Lung neoplasms; Epidemiology; Korea; Never-smokers; Epidermal growth factor receptor
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