J Prev Med Public Health.  2019 Sep;52(5):277-280. 10.3961/jpmph.19.018.

Introduction of Vaccinomics to Develop Personalized Vaccines in Light of Changes in the Usage of Hantaan Virus Vaccine (Hantavax®) in Korea

• Bae JM

• KMID: 2460208
• DOI: http://doi.org/10.3961/jpmph.19.018

Abstract

The Ministry of Food and Drug Safety of Korea made an official announcement in March 2018 that the total number of inoculations of Hantaan virus vaccine (Hantavax®) would change from 3 to 4. Some aspects of this decision remain controversial. Based on the characteristics of Hantaan virus (HTNV) and its role in the pathogenesis of hemorrhagic fever with renal syndrome, it might be difficult to develop an effective and safe HTNV vaccine through the isolate-inactivate-inject paradigm. With the development of high-throughput "˜omics' technologies in the 21st century, vaccinomics has been introduced. While the goal of vaccinomics is to develop equations to describe and predict the immune response, it could also serve as a tool for developing new vaccine candidates and individualized approaches to vaccinology. Thus, the possibility of applying the innovative field of vaccinomics to develop a more effective and safer HTNV vaccine should be considered.

Keyword

Hantaan virus; Hemorrhagic fever with renal syndrome; Synthetic vaccines; Immunogenetics; Precision medicine

MeSH Terms

Hantaan virus*
Hemorrhagic Fever with Renal Syndrome
Humans
Immunogenetics
Korea*
Precision Medicine
Vaccines*
Vaccines, Synthetic
Vaccines
Vaccines, Synthetic