J Korean Ophthalmol Soc.  2019 Sep;60(9):821-828. 10.3341/jkos.2019.60.9.821.

Effectiveness of Cyclosporine-steroid Treatment after Cataract Surgery according to Dry Eye Severity

• Park JY
• Yang SC
• Park YM
• Lee JE
• Park CY
• Lee JS

• KMID: 2459125
• DOI: http://doi.org/10.3341/jkos.2019.60.9.821

Abstract

PURPOSE
To evaluate the effectiveness of topically administered 0.05% cyclosporine combined with a topical steroid in the early postoperative period after cataract surgery, and to compare the therapeutic efficacy according to the severity of dry eye.
METHODS
One hundred and fifty-six patients who underwent unilateral cataract surgery and received topical cyclosporine 0.05% for 8 weeks combined with a fluorometholone 0.1% steroid for 4-weeks were classified into three groups according to preoperative dry eye level: the control group, non-dry eye (n = 78); group 1, level I dry eye (n = 38); and group 2, level II dry eye (n = 40). The best-corrected distance visual acuity, intraocular pressure, dry eye symptom questionnaire (ocular surface disease index), tear film break-up time (TBUT), and Schirmer test-I (STI) were evaluated.
RESULTS
The preoperative score of dry eye symptoms improved significantly at one week postoperatively and continued to improve until postoperative 8-weeks in all groups, especially in group 2 compared with the control. Groups 1 and 2 showed significant improvement in the TBUT at one week, four weeks, and eight weeks postoperatively, compared to eight weeks postoperatively in the control; Group 2, especially, showed significant improvement in TBUT. There was no difference in STI value after cyclosporine-steroid treatment in the control group; however, a significant difference was observed at four weeks postoperatively in dry eyes. No significant differences in STI results were observed among the three groups.
CONCLUSIONS
Use of topical cyclosporine 0.05% combined with a topical fluorometholone 0.1% steroid after cataract surgery is more effective in dry eyes level II than in non-dry eyes, especially those with TBUT and dry eye symptoms at eight weeks postoperatively.

Keyword

Cataract surgery; Cyclosporine; Dry eye syndrome

MeSH Terms

Cataract*
Cyclosporine
Dry Eye Syndromes
Fluorometholone
Humans
Intraocular Pressure
Postoperative Period
Sexually Transmitted Diseases
Tears
Visual Acuity
Cyclosporine
Fluorometholone