J Korean Diabetes.  2019 Sep;20(3):149-156. 10.4093/jkd.2019.20.3.149.

Injectable Therapy for Diabetes Mellitus: Glucagon-Like Peptide-1 Receptor Agonist

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. edgo@yuhs.ac
  • 2Severance Hospital Diabetes Center, Seoul, Korea.
  • 3Institute of Endocrine Research, Yonsei University College of Medicine, Seoul, Korea.

Abstract

According to the American Diabetes Association (ADA) and the European Association for the Study of Diabetes guideline for treatment of diabetes, glucagon-like peptide-1 receptor agonist (GLP-1 RA) is recommended in diabetic patients with established atherosclerotic cardiovascular disease. This recommendation is based on the results of recent cardiovascular outcome trials of this kind of medications. GLP-1 RAs have a glucose lowering effect with weight loss and a lower incidence of hypoglycemia, and can improve cardiovascular outcomes such as three-point major cardiovascular events composed of death from cardiovascular causes, non-fatal myocardial infarction, and non-fatal stroke. Also, several GLP-1 RAs have beneficial effects on renal outcomes, mainly due to improvement in macroalbuminuria. In addition, high-dose liraglutide (3 mg/day subcutaneous injection) showed efficacy for reducing body weight. Therefore GLP-1 RA may be effective in patients with established cardiovascular disease, chronic kidney disease, and/or metabolic syndrome.

Keyword

Cardiovascular diseases; Diabetes mellitus; Glucagon-like peptide-1; Kidney diseases; Obesity

MeSH Terms

Body Weight
Cardiovascular Diseases
Diabetes Mellitus*
Glucagon-Like Peptide 1*
Glucagon-Like Peptide-1 Receptor*
Glucose
Humans
Hypoglycemia
Incidence
Kidney Diseases
Liraglutide
Myocardial Infarction
Obesity
Renal Insufficiency, Chronic
Stroke
Weight Loss
Glucagon-Like Peptide 1
Glucagon-Like Peptide-1 Receptor
Glucose
Liraglutide
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