J Breast Cancer.  2019 Sep;22(3):484-490. 10.4048/jbc.2019.22.e31.

Human Epidermal Growth Factor Receptor 2-Subtype Invasive Ductal Carcinoma Recurring as Basal-Human Epidermal Growth Factor Receptor 2-Subtype Squamous Cell Carcinoma

Affiliations
  • 1Department of Surgery, Ewha Womans University School of Medicine, Seoul, Korea. mbit@ewha.ac.kr
  • 2Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea.
  • 3Department of Hematology-Oncology, Ewha Woman's University School of Medicine, Seoul, Korea.

Abstract

Squamous cell carcinoma of the breast and its subtype, basal-human epidermal growth factor receptor 2 (HER2) phenotype, are very rare. Herein, we report a patient who developed recurrence of squamous cell carcinoma of the breast with basal-HER2 subtype 6 years after the initial diagnosis of invasive ductal carcinoma of the HER2 subtype. To the best of our knowledge, recurrence of invasive ductal carcinoma in the form of metaplastic squamous cell carcinoma of basal-HER2 subtype has not been reported previously. We present a pathological perspective of our experience.

Keyword

Breast; Ductal carcinoma; Pathology; Squamous cell carcinoma

MeSH Terms

Breast
Carcinoma, Ductal*
Carcinoma, Squamous Cell
Diagnosis
Epidermal Growth Factor*
Humans*
Pathology
Phenotype
Receptor, Epidermal Growth Factor*
Recurrence
Epidermal Growth Factor
Receptor, Epidermal Growth Factor
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