J Gastric Cancer.  2019 Mar;19(1):83-91. 10.5230/jgc.2019.19.e4.

Oncologic Outcomes after Laparoscopic and Open Distal Gastrectomy for Advanced Gastric Cancer: Propensity Score Matching Analysis

Affiliations
  • 1Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea. drchoi@khu.ac.kr
  • 2Department of Surgery, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea.

Abstract

PURPOSE
This study aimed to compare the oncologic and short-term outcomes of laparoscopic distal gastrectomy (LDG) and open distal gastrectomy (ODG) for advanced gastric cancer (AGC).
MATERIALS AND METHODS
From July 2006 to November 2016, 384 patients underwent distal gastrectomy for AGC. Data on short- and long-term outcomes were prospectively collected and reviewed. Propensity score matching was applied at a ratio of 1:1 to compare the LDG and ODG groups.
RESULTS
The operative times were longer for the LDG group than for the ODG group. However, the time to resumption of diet and the length of hospital stay were shorter in the LDG group than in the ODG group (4.7 vs. 5.6 days, P=0.049 and 9.6 vs. 11.5 days, P=0.035, respectively). The extent of lymph node dissection in the LDG group was more limited than in the ODG group (P=0.002), although there was no difference in the number of retrieved lymph nodes between the 2 groups. The 3-year overall survival rates were 98% and 86.9% (P=0.018), and the 3-year recurrence-free survival rates were 86.3% and 75.3% (P=0.259), respectively, in the LDG and ODG groups.
CONCLUSIONS
LDG is safe and feasible for AGC, with earlier recovery after surgery and long-term oncologic outcomes comparable to those of ODG.

Keyword

Stomach neoplasms; Laparoscopy; Disease-free survival

MeSH Terms

Diet
Disease-Free Survival
Gastrectomy*
Humans
Laparoscopy
Length of Stay
Lymph Node Excision
Lymph Nodes
Operative Time
Propensity Score*
Prospective Studies
Stomach Neoplasms*
Survival Rate

Figure

  • Fig. 1 RFS after propensity score matching analysis. RFS = recurrence-free survival; LDG = laparoscopic distal gastrectomy; ODG = open distal gastrectomy.

  • Fig. 2 OS after propensity score matching analysis. OS = overall survival; LDG = laparoscopic distal gastrectomy; ODG = open distal gastrectomy.


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