Brain Neurorehabil.  2019 Sep;12(2):e14. 10.12786/bn.2019.12.e14.

Effect of White Matter Hyperintensity on the Functional Outcome of Ischemic Stroke Patients after Inpatient Stroke Rehabilitation

  • 1Department of Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul, Korea.
  • 2Department of Rehabilitation Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
  • 3Department of Medicine, Kyung Hee University, Seoul, Korea.


The aim of the study is to investigate the association between cerebral white matter hyperintensity (WMH) and the functional improvement using the Korean version of Modified Barthel Index (K-MBI) score during inpatient stroke rehabilitation. One hundred sixty participants were divided into 2 groups based on the severity of WMH according to Fazekas scale: Mild WMH group was defined as patients with Fazekas scale 0 and 1, and severe WMH group was defined as Fazekas scale 2 and 3. Functional status was assessed using the K-MBI score, and functional gains were calculated from the K-MBI score. The absolute functional gain in mild WMH group was significantly higher compared to severe WMH group (p < 0.05). In addition, patients in mild WMH had higher absolute functional efficiency, rehabilitation effectiveness, and relative functional efficiency. In the generalized linear model analyses, there was an association between functional outcomes and severity of WMH. In this study, the severity and extent of WMH are significantly correlated with poor functional improvement in patients with ischemic stroke. The WMH could be considered as one of many factors that can influence functional recovery during rehabilitation of stroke.


White Matter; Stroke Rehabilitation; Recovery of Function; Inpatients
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