Brain Neurorehabil.  2019 Sep;12(2):e9. 10.12786/bn.2019.12.e9.

Incidence and Clinical Characteristics of Ischemic Stroke Patients with Underlying Cancer

  • 1Department of Physical Medicine and Rehabilitation, Korea University Medical Center, Seoul, Korea.
  • 2Department of Physical Medicine and Rehabilitation, Catholic Kwandong University International St. Mary's Hospital, Incheon, Korea.
  • 3Brain Convergence Research Center, Korea University, Seoul, Korea.


Cancer and ischemic stroke (IS) are leading causes of death and disability, worldwide. It is reported that cancer increases IS incidence with various unknown mechanism. We retrospectively reviewed medical records of single tertiary medical center between January 2012 and December 2016. A total of 40,047 patients with cancer were analyzed and 63 patients (0.16%) were diagnosed of IS with underlying cancer. Lung (27.0%), gastric (14.3%) and colorectal (12.7%) cancers were the most frequent types of cancers and adenocarcinoma was the most common histologic type. We compared the clinical variables (demographic data, comorbidities, cancer stage, infarction pattern and severity) between adenocarcinoma and non-adenocarcinoma groups. And the results showed low coexistence of dyslipidemia and smoking history, and higher rate of multiple vascular territory infarct in adenocarcinoma group (p < 0.05). Six-month post stroke mortality rate was 34.6% and systemic metastasis and multi-territorial infarction were significantly relevant with the six-month mortality (p < 0.001). Also, initial National Institute of Health Stroke Scale (p < 0.05) and modified Rankin Scale scores were statistically significantly worse in mortality group (p < 0.05). In conclusion, the most frequent cancer type was lung cancer and adenocarcinoma the most common histologic type. Mortality at 6-month post stroke was high, and it was associated with stage of cancer and initial neurological severity.


Cancer; Ischemic Stroke; Adenocarcinoma; Mortality
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