Clin Psychopharmacol Neurosci.  2019 Mar;17(2):308-313. 10.9758/cpn.2019.17.2.308.

Effect of Maternal Depression on Brain-derived Neurotrophic Factor Levels in Fetal Cord Blood

Affiliations
  • 1Department of Psychiatry, Dr. Ekrem Tok Mental Health and Disease Hospital, Adana, Turkey. eondersonmez@gmail.com
  • 2Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
  • 3Department of Pediatrics, Çukurova University, Adana, Turkey.
  • 4Department of Psychiatry, AfÅŸin State Hospital, Kahramanmaras, Turkey.
  • 5Department of Neonatology, Konya Research and Training Hospital, Konya, Turkey.
  • 6Department of Obstetrics and Gynecology, Konya Research and Training Hospital, Konya, Turkey.
  • 7Department of Obstetrics and Gynecology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
  • 8Department of Biochemistry, Konya Research and Training Hospital, Konya, Turkey.
  • 9Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.

Abstract

OBJECTIVE: We aimed to assess the association between cord blood brain-derived neurotrophic factor (BDNF) concentration and maternal depression during pregnancy.
METHODS
A total of 48 pregnant women, admitted for elective caesarean section to Department of Obstetrics and Gynecology, The Konya Research and Training Hospital and Konya Necmettin Erbakan University Meram Medical Faculty, were included in this study. The study group included 23 women diagnosed as having depression during pregnancy and the control group included 25 pregnant women who did not experience depression during pregnancy.
RESULTS
The groups had similar sociodemographic characteristics. Cord blood BDNF concentration was significantly lower in babies born to mothers with major depression as compared with those in the control group. We didn't find any correlation between the umbilical cord blood BDNF levels and BDI scores.
CONCLUSION
The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels.

Keyword

Brain-derived neurotrophic factor; Pregnancy; Depression; Fetal cord blood; Neurodevelopment
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