Mycobiology.  2019 Mar;47(1):112-119. 10.1080/12298093.2019.1568680.

Anti-Melanogenic Effect from Submerged Mycelial Cultures of Ganoderma weberianum

  • 1Department of Food Science, National Quemoy University, Kinmen, Taiwan.
  • 2Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.,
  • 3Graduate Institute of Food Science Technology, National Taiwan University, Taipei, Taiwan.
  • 4Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan.
  • 5Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.


Compounds from Lingzhi has been demonstrated the ability for inhibiting tyrosinase (a key enzyme in melanogenesis) activity. In this study, we investigated the anti-melanogenic activity from the submerged mycelial culture of Ganoderma weberianum and elucidated the skin lightening mechanism by B16-F10 murine melanoma cells. From the cellular context, several fractionated mycelium samples exhibited anti-melanogenic activity by reducing more than 40% extracellular melanin content of B16-F10 melanoma cells. In particular, the fractionated chloroform extract (CF-F3) inhibited both secreted and intracellular melanin with the lowest dosage (25 ppm). Further analysis demonstrated that CF-F3 inhibited cellular tyrosinase activity without altering its protein expression. Taken together, our study has demonstrated that the chemical extracts from submerged mycelial culture of G. weberianum have the potential to serve as an alternative anti-melanogenic agent.


Word; Ganoderma weberianum; skin lightening; anti-melanogenesis; tyrosinase inhibitor
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