Nucl Med Mol Imaging.  2019 Aug;53(4):235-241. 10.1007/s13139-019-00598-7.

Measurement of Tumor Pressure and Strategies of Imaging Tumor Pressure for Radioimmunotherapy

Affiliations
  • 1Division of RI application, Korea Institute of Radiological and Medical Sciences & Radiological andMedico-Oncological Sciences, University of Science and Technology (UST), 75 Nowon-Gil, Gongneung-Dong, Nowon-Gu, Seoul 01812, South Korea. kjs@kirams.re.kr
  • 2Laboratory Animal center, Osong Medical Innovation Foundation, Cheongju, Chungbuk, South Korea.
  • 3Department of NuclearMedicine, Korea Institute of Radiological and Medical Sciences, Nowon-gu, South Korea.
  • 4Radiological and Medico-Oncological Sciences, University of Science and Technology (UST), Seoul, South Korea.

Abstract

Tumor interstitial pressure is a fundamental feature of cancer biology. Elevation in tumor pressure affects the efficacy of cancer treatment and results in the heterogenous intratumoral distribution of drugs and macromolecules. Monoclonal antibodies (mAb) play a prominent role in cancer therapy and molecular nuclear imaging. Therapy using mAb labeled with radionuclides"”also known as radioimmunotherapy (RIT)"”is an effective form of cancer treatment. RIT is clinically effective for the treatment of lymphoma and other blood cancers; however, its clinical use for solid tumor was limited because their high interstitial pressure prevents mAb from penetrating into the tumor. This pressure can be decreased using anti-cancer drugs or additional external therapy. In this paper, we reviewed the intratumoral pressure using direct tumor-pressure measurement strategies, such as the wick-in-needle and pressure catheter transducer method, and indirect tumor-pressure measurement strategies via magnetic resonance.

Keyword

Tumor pressure; Monoclonal antibody; Radioimmunotherapy; ADC

MeSH Terms

Antibodies, Monoclonal
Biology
Catheters
Lymphoma
Methods
Radioimmunotherapy*
Transducers
Antibodies, Monoclonal
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