Clin Exp Otorhinolaryngol.  2019 Aug;12(3):301-307. 10.21053/ceo.2018.01781.

Long-term Breastfeeding in the Prevention of Allergic Rhinitis: Allergic Rhinitis Cohort Study for Kids (ARCO-Kids Study)

Affiliations
  • 1Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea. csrhee@snu.ac.kr
  • 2Department of Otorhinolaryngology, Soonchunhyang University College of Medicine, Seoul, Korea.
  • 3Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. suepark@snu.ac.kr
  • 4Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea.
  • 5Cancer Research Institute, Seoul National University, Seoul, Korea.
  • 6Department of Otolaryngology-Head and Neck Surgery, Chonbuk National University Medical School, Jeonju, Korea.
  • 7Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.
  • 8Department of Otolaryngology-Head and Neck Surgery, Kyung Hee University School of Medicine, Seoul, Korea.
  • 9Department of Otolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
  • 10Department of Otorhinolaryngology-Head and Neck Surgery, Inha University College of Medicine, Incheon, Korea.
  • 11Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine, Busan, Korea.
  • 12Department of Otorhinolaryngology-Head and Neck Surgery, Chungbuk National University College of Medicine, Cheongju, Korea.
  • 13Department of Otolaryngology-Head and Neck Surgery, Chungnam National University School of Medicine, Daejeon, Korea.
  • 14Department of Otorhinolaryngology, Gyeongsang National University Hospital, Jinju, Korea.
  • 15Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.
  • 16Department of Otolaryngology-Head and Neck Surgery, Ewha Womans University School of Medicine, Seoul, Korea.
  • 17Department of Otorhinolaryngology-Head and Neck Surgery, SMG-SNU Boramae Medical Center, Seoul, Korea.
  • 18Graduate School of Immunology, Seoul National University College of Medicine, Seoul, Korea.
  • 19Institute of Allergy and Clinical Immunology, Seoul National University Biomedical Research Center, Seoul, Korea.
  • 20Sensory Organ Research Institute, Seoul National University Biomedical Research Center, Seoul, Korea, Korea.

Abstract


OBJECTIVES
There is a great deal of interest in the possibility that environmental factors may influence the risk of developing allergic rhinitis (AR) in early life. We investigated the simultaneous effects of mode of delivery and duration of breastfeeding on the development of AR in children.
METHODS
Data from 1,374 children participating in the Allergic Rhinitis Cohort Study for kids (ARCO-kids study) was analyzed. All subjects were divided into AR or non-allergic rhinitis (NAR) groups. Data on environmental factors, mode of delivery and duration of breastfeeding were collected using a questionnaire.
RESULTS
Compared with short-term breastfeeding (<6 months), long-term breastfeeding (≥12 months) was significantly associated with a lower prevalence of AR (adjusted odds ratio [aOR], 0.54; 95% confidence interval [CI], 0.34 to 0.88). Children in the AR group also had a higher cesarean delivery rate than those in the NAR group (39.1% vs. 32.8%, P=0.05). Regarding the combined effects of mode of delivery and duration of breastfeeding, long-term breastfeeding with a vaginal delivery strongly suppressed the development of AR, compared to short-term breastfeeding with a cesarean delivery (aOR, 0.47; 95% CI, 0.30 to 0.73).
CONCLUSION
Long-term breastfeeding (≥12 months) and a vaginal delivery are associated with a lower risk of developing childhood AR.

Keyword

Rhinitis, Allergic; Breast Feeding; Environment; Delivery, Obstetric; Cesarean Section
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