Clin Exp Vaccine Res.  2019 Jul;8(2):103-109. 10.7774/cevr.2019.8.2.103.

Effect of simultaneous administration of foot-and-mouth disease (FMD) and anthrax vaccines on antibody response to FMD in sheep

Affiliations
  • 1Republic of Turkey Ministry of Agriculture and Forestry, Institute of Foot and Mouth Disease (SAP), Ankara, Turkey. cancokcaliskan@gmail.com

Abstract

PURPOSE
Foot-and-mouth disease (FMD) and anthrax are important diseases in sheep. Vaccination is a favorable strategy against both infections. Simultaneous administration of vaccines does generally not impede the immune responses of each other, although there are some exceptions, and it may help reduce the labor and costs of vaccination as well as distress on animals. Although oil adjuvant FMD vaccine has been tried with live anthrax vaccine in cattle, there are no reports on the simultaneous use of both vaccines in sheep.
MATERIALS AND METHODS
In this study, FMD seronegative sheep were used to investigate the impact of the simultaneous vaccination of FMD and anthrax on FMD antibody titers of sheep. Virus neutralization test and liquid phase blocking enzyme-linked immunosorbent assay were used to determine the antibody response to the FMD vaccine.
RESULTS
The results demonstrated that both vaccines can be used simultaneously without any interference with the FMD response. Moreover, the simultaneous administration with anthrax vaccine had a stimulating effect on the early (day 7 post-vaccination) virus neutralization antibody response to the FMD vaccine.
CONCLUSION
The simultaneous use of the FMD and anthrax vaccines did not hinder the response to the FMD vaccine in sheep.

Keyword

Foot-and-mouth disease; Anthrax; Simultaneous vaccination; Sheep; Virus neutralization

MeSH Terms

Animals
Anthrax Vaccines*
Anthrax*
Antibody Formation*
Cattle
Enzyme-Linked Immunosorbent Assay
Foot-and-Mouth Disease*
Neutralization Tests
Sheep*
Vaccination
Vaccines
Anthrax Vaccines
Vaccines

Figure

  • Fig. 1 (A) The post-vaccinal arithmetic means of virus-neutralizing antibody titers against OTUR/07 for the experiment groups. (B) The post-vaccinal arithmetic means of virus-neutralizing antibody titers against ANEP/84 for the experiment groups. (C) The post-vaccinal arithmetic means of virus-neutralizing antibody titers against ASTUR/15 for the experiment groups. FMD, foot-and-mouth disease.

  • Fig. 2 (A) The post-vaccinal arithmetic means of the liquid phase blocking enzyme-linked immunosorbent assay (LPBE) antibody titers against OTUR07 for the experiment groups. (B) The post-vaccinal arithmetic means of the LPBE antibody titers against ANEP/84 for the experiment groups. (C) The post-vaccinal arithmetic means of the LPBE antibody titers against ASTUR/15 for the experiment groups. FMD, foot-and-mouth disease.


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