Ewha Med J.  2019 Jul;42(3):39-45. 10.12771/emj.2019.42.3.39.

Assessment of Right Ventricular Function by Tissue Doppler Imaging in Pulmonary Arterial Hypertensive Rat

Affiliations
  • 1Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea. ymhong@ewha.ac.kr
  • 2Department of Thorax and Cardiovascular Surgery, Ewha Womans University College of Medicine, Seoul, Korea.

Abstract


OBJECTIVES
Elevated pulmonary pressure and right ventricular (RV) dysfunction are the hallmarks of pulmonary vascular disease in animal models and human patients with pulmonary arterial hypertension (PAH). Monocrotaline models of PAH are widely used to study the pathophysiology of PAH. The purpose of this study was to evaluate the severity of PAH rat model by tissue Doppler imaging (TDI).
METHODS
PAH was induced in Sprague-Dawley rats by monocrotaline (M) group. The peak systolic (s'), early diastolic (e'), and late diastolic myocardial velocities (a') were measured using TDI at basal segments. Tricuspid annular plane systolic excursion (TAPSE) was measured in the 4-chamber view. Velocity of a tricuspid regurgitation (TR) jet was measured to estimate the pulmonary artery pressure to assess the severity of PAH.
RESULTS
Decrease in the RV shortening fraction and ejection fraction were observed in the M group compared with the control (C) group. RV e' velocity and s' velocity were significantly lower in the M group compared with the C group. The TAPSE was significantly lower in the M group compared with the C group (1.26±0.22 mm vs. 2.83±0.34 mm). The TR velocity was significantly higher in the M group compared with the C group (4.48±0.34 m/sec vs. 1.23±0.02 m/sec).
CONCLUSION
TAPSE is an easily obtainable, widely recognized and clinically useful echocardiographic parameter of global RV function in the PAH rat model. We recommend that TDI would be a helpful diagnostic tool to evaluate the RV function in PAH rat model.

Keyword

Hypertension, pulmonary; Monocrotaline; Echocardiography; Right ventricular dysfunction

MeSH Terms

Animals
Echocardiography
Humans
Hypertension
Hypertension, Pulmonary
Models, Animal
Monocrotaline
Pulmonary Artery
Rats*
Rats, Sprague-Dawley
Tricuspid Valve Insufficiency
Vascular Diseases
Ventricular Dysfunction, Right
Ventricular Function, Right*
Monocrotaline
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