Cancer Res Treat.  2019 Jul;51(3):1249-1256. 10.4143/crt.2018.451.

Prospective Validation of The Korean Cancer Study Group Geriatric Score (KG)-7, a Novel Geriatric Screening Tool, in Older Patients with Advanced Cancer Undergoing First-line Palliative Chemotherapy

• Kim JW
• Kim SH
• Lee YG
• Hwang IG
• Kim JY
• Koh SJ
• Ko YH
• Shin SH
• Woo IS
• Hong S
• Kim TY
• Baek JY
• Kim HJ
• Kim HJ
• Lee MA
• Kwon JH
• Hong YS
• Ryoo HM
• Lee KH
• Kim JH

• KMID: 2454316
• DOI: http://doi.org/10.4143/crt.2018.451

Abstract

PURPOSE
The purpose of this study was to prospectively validate the Korean Cancer Study Group Geriatric Score (KG)-7, a novel geriatric screening tool, in older patients with advanced cancer planned to undergo first-line palliative chemotherapy.
MATERIALS AND METHODS
Participants answered the KG-7 questionnaire before undergoing geriatric assessment (GA) and first-line palliative chemotherapy. The performance of KG-7 was evaluated by calculating the sensitivity (SE), specificity (SP), positive and negative predictive value (PPV and NPV), balanced accuracy (BA), and area under the curve (AUC).
RESULTS
The baseline GA and KG-7 results were collected from 301 patients. The median age was 75 years (range, 70 to 93 years). Abnormal GA was documented in 222 patients (73.8%). Based on the ≤ 5 cut-off value of KG-7 for abnormal GA, abnormal KG-7 score was shown in 200 patients (66.4%). KG-7 showed SE, SP, PPV, NPV, and BA of 75.7%, 59.7%, 84.4%, 46.0%, and 67.7%, respectively; AUC was 0.745 (95% confidence interval, 0.687 to 0.803). Furthermore, patients with higher KG-7 scores showed significantly longer survival (p=0.006).
CONCLUSION
KG-7 appears to be adequate in identifying patients with abnormal GA prospectively. Hence, KG-7 can be a useful screening tool for Asian countries with limited resources and high patient volume.

Keyword

Geriatric assessment; KG-7; Screening tools; Prospective; Validation

MeSH Terms

Area Under Curve
Asian Continental Ancestry Group
Drug Therapy*
Geriatric Assessment
Humans
Mass Screening*
Prospective Studies*
Sensitivity and Specificity

Figure

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  Fig. 1. Distribution of Korean Cancer Study Group Geriatric Score (KG)-7 score according to status of geriatric assessment (GA). Values shown in Table are presented as number (%).

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  Fig. 2. Receiver operating characteristic (ROC) curve comparing Korean Cancer Study Group Geriatric Score (KG)-7 (A) with Geriatric 8 (G-8) (B). CI, confidence interval.

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  Fig. 3. Overall survival according to normal Korean Cancer Study Group Geriatric Score (KG)-7 vs. abnormal KG-7 score (A), overall survival based on subgroups of KG-7 scores (B).

Reference

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