Int J Oral Biol.  2019 Jun;44(2):55-61. 10.11620/IJOB.2019.44.2.55.

Effect of Garcinia mangostana L. and propolis extracts on the inhibition of inflammation and alveolar bone loss in ligature-induced periodontitis in rats

Affiliations
  • 1Department of Periodontology, School of Dentistry, Chosun University, Gwangju 61452, Republic of Korea. sjyu78@chosun.ac.kr
  • 2Medi Bio Lab Co., Ltd., Seoul 08389, Republic of Korea. dsl2008@naver.com
  • 3Korean Collection for Oral Microbiology, School of Dentistry, Chosun University, Gwangju 61452, Republic of Korea.
  • 4Department of Oral Biochemistry, School of Dentistry, Chosun University, Gwangju 61452, Republic of Korea.

Abstract

The purpose of this study was to evaluate the effect of mangosteen extract complex (MEC; Garcinia mangostana L. and propolis extracts) on the inhibition of inflammation and prevention of alveolar bone loss using a ligature-induced periodontitis model. Rat molars were ligatured with silk, and 1 µg/mL of lipopolysaccharide of Porphyromonas gingivalis was injected into the buccal and palatal gingivae of the teeth with or without treatment with the MEC. Changes in the expression levels of prostaglandin E₂ (PGE₂), interleukin-8 (IL-8), inducible nitric oxide synthase (iNOS), matrix metalloproteinase-8 (MMP-8), cyclooxygenase (COX)-1, and COX-2 in gingival tissues were evaluated using enzyme-linked immunosorbent assays. Alveolar bone loss around the ligated molars was examined using micro-computed tomography. The expression levels of PGE₂, IL-8, iNOS, MMP-8, COX-1, and COX-2 in gingival tissues were significantly reduced in the group treated with a mixture of 16 µg of mangosteen extract powder and 544 µg of propolis extract powder (ligation [Lig] + lipopolysaccharide extracted from P. gingivalis KCOM 2804 [L] + MEC 1:34). Additionally, alveolar bone loss was significantly reduced in the Lig + L + MEC 1:34 group compared with that in other groups. These results indicate that the MEC could be useful in preventing and treating periodontitis.

Keyword

Mangosteen extract complex; Anti-inflammatory; Alveolar bone loss
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