Ann Dermatol.  2019 Aug;31(4):393-402. 10.5021/ad.2019.31.4.393.

Increased Circulating CXCL10 in Non-Segmental Vitiligo Concomitant with Autoimmune Thyroid Disease and Alopecia Areata

Affiliations
  • 1Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China. flora_xiang@vip.163.com, e3dangdang@hotmail.com

Abstract

BACKGROUND
Vitiligo is a common acquired pigmentary disease caused by destruction of epidermal melanocytes in underlying autoimmune response. Few studies have been focused on the role of chemokines in non-segmental vitiligo (NSV) concomitant with autoimmune thyroid disease (AITD) and alopecia areata (AA).
OBJECTIVE
The aim of this study was to determine the best serum biomarker for predictive role in the progression of vitiligo and to evaluate the influence of AA and/or AITD on vitiligo by using the biomarker.
METHODS
This prospective cohort study recruited 45 NSV patients: 14 without either AITD or AA, 12 with AITD, 11 with AA, and 8 with both AITD and AA. Serum levels of CXCL1, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13, and CXCL16 were analyzed by ELISA. CXCR3 mRNA expression was detected on PBMCs by RT-PCR. Improvement was evaluated using repigmentation scales.
RESULTS
Serum CXCL10 levels, along with the expression of CXCR3 mRNA were higher in NSV patients with AITD or AA alone than in those without AITD or AA. Moreover, serum CXCL10 levels, along with the expression of CXCR3 mRNA were higher in NSV patients with both AITD and AA than in those with AITD or AA alone. Poorer repigmentation was observed in NSV patients with both AA and AITD than in those with AA or AITD alone.
CONCLUSION
CXCL10 could be a biomarker to predict the progression of NSV. Dermatologists should pay much attention to those NSV patients concomitant with AITD and/or AA, for comorbidity might lead to more active autoimmune reaction.

Keyword

Alopecia areata; Autoimmunity; Chemokine CXCL10; Thyroid diseases; Vitiligo

MeSH Terms

Alopecia Areata*
Alopecia*
Autoimmunity
Chemokine CXCL10
Chemokines
Cohort Studies
Comorbidity
Enzyme-Linked Immunosorbent Assay
Humans
Melanocytes
Prospective Studies
RNA, Messenger
Thyroid Diseases*
Thyroid Gland*
Vitiligo*
Weights and Measures
Chemokine CXCL10
Chemokines
RNA, Messenger
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