Anat Cell Biol.
2019 Jun;52(2):196-203. 10.5115/acb.2019.52.2.196.
Vitamin C restores ovarian follicular reservation in a mouse model of aging
- Affiliations
-
- 1Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- 2Abnormal Uterine Bleeding Research Center, Semnan University of Medical Sciences, Semnan, Iran.
- 3School of Nursing and Midwifery, Lorestan University of Medical Sciences, Tehran, Iran.
- 4Department of Anatomical Sciences & Cognitive Neuroscience, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. sh.abdi@iautmu.ac.ir
- KMID: 2451224
- DOI: http://doi.org/10.5115/acb.2019.52.2.196
Abstract
- Ovarian aging is related to the reduction of oocyte quality and ovarian follicles reservation leading to infertility. Vitamin C is a natural antioxidant which may counteract with adverse effects of aging in the ovary. The aim of this study was to evaluate the possible effect of vitamin C on NMRI mice ovarian aging according to the stereological study. In this experimental study, 36 adult female mice (25-30 g) were divided into two groups: control and vitamin C. Vitamin C (150 mg/kg/day) were administered by oral gavage for 33 weeks. Six animals of each group were sacrificed on week 8, 12, and 33, and right ovary samples were extracted for stereology analysis. Our data showed that the total volume of ovary, cortex, medulla and corpus luteum were significantly increased in vitamin C group in comparison to the control groups (P≤0.05). In addition, the total number of primordial, primary, secondary, and antral follicles as well as granulosa cells were improved in vitamin C group in compared to the control groups (P≤0.05). No significant difference was observed in total volume of oocytes in antral follicles between control and vitamin C groups. Our data showed that vitamin C could notably compensate undesirable effects of ovarian aging in a mouse model.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Impact of vitamin D3 supplementation on the in vitro growth of mouse preantral follicles
- Effects of Ketamine and Pentobarbitone on Degeneration of Oocyte and of Granulosa Cells in Mouse Ovary
- Expression of SDF-1alpha and leptin, and their effect on expression of angiogenic factors in mouse ovaries
- The Effect of Polycystic Ovarian Follicular Fluid on Sperm Motility in Human in vitro Fertilization
- Assessment of Follicular Maturation by Plasma Estradiol Levels and Ultrasound During Normal Periovulatory Period
