J Clin Neurol.  2019 Jan;15(1):125-127. 10.3988/jcn.2019.15.1.125.

A Case of Anti-N-Methyl-D-Aspartate Receptor Encephalitis Associated with Glioma of the Pons

Affiliations
  • 1Università degli Studi di Milano-Bicocca-School of Neurology, Milano, Italy. franci.beretta@hotmail.com
  • 2Department of Neurology, ASST Lecco, Lecco, Italy.
  • 3Department of Nuclear Medicine, ASST Lecco, Lecco, Italy.

Abstract

No abstract available.


MeSH Terms

Anti-N-Methyl-D-Aspartate Receptor Encephalitis*
Glioma*
Pons*

Figure

  • Fig. 1 MRI and 18F-FDG-PET/CT images obtained at the onset of anti-NMDA-receptor encephalitis (A, B, and C) and after relapse (D, E, and F). FLAIR axial images obtained at disease onset (A) and control obtained several months after relapse (D). The residual glioma (arrows) can be seen extending into the fourth ventricle in both images (A and D), with a minimal increase in size and a signal hyperintensity evident in the second one. B and C: 18F-FDG-PET/CT images obtained at disease onset, which show severe hypometabolism in the occipital regions and reduced tracer uptake in the basal ganglia. E and F: 18F-FDG-PET/CT images obtained after relapse, showing an uneven distribution of the tracer but no specific hypometabolic area. Signs of previously operated frontal head trauma are evident in both 18F-FDG-PET/CT images. CT: computed tomography, 18F-FDG: 18F-fluorodeoxyglucose, FLAIR: fluidattenuated inversion recovery, MRI: magnetic resonance imaging, NMDA: N-Methyl-D-Aspartate, PET: positron emission tomography.


Reference

1. Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011; 10:63–74.
Article
2. Liu CY, Zhu J, Zheng XY, Ma C, Wang X. Anti-N-methyl-D-aspartate receptor encephalitis: a severe, potentially reversible autoimmune encephalitis. Mediators Inflamm. 2017; 2017:6361479.
Article
3. Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. 2016; 15:391–404.
Article
4. Palygin O, Lalo U, Pankratov Y. Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes. Br J Pharmacol. 2011; 163:1755–1766.
Article
5. Probasco JC, Solnes L, Nalluri A, Cohen J, Jones KM, Zan E, et al. Decreased occipital lobe metabolism by FDG-PET/CT: an anti-NMDA receptor encephalitis biomarker. Neurol Neuroimmunol Neuroinflamm. 2017; 5:e413.
6. Tripathi M, Tripathi M, Roy SG, Parida GK, Ihtisham K, Dash D, et al. Metabolic topography of autoimmune non-paraneoplastic encephalitis. Neuroradiology. 2018; 60:189–198.
Article
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