Dement Neurocogn Disord.  2019 Jun;18(2):62-68. 10.12779/dnd.2019.18.2.62.

Effect of Paper-Based Cognitive Training in Early Stage of Alzheimer's Dementia

Affiliations
  • 1Department of Neurology, Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Korea. astro76@naver.com
  • 2Hanam City Public Health Center, Hanam, Korea.

Abstract

BACKGROUND AND PURPOSE
Cognitive training refers to a series of standardized tasks with inherent challenges that target specific cognitive domains. Positive outcome of cognitive training in persons with Alzheimer's disease has been reported. In this study, the objective was to design sets of cognitive training program, "Gipum-seo" which is combined cognitive training, consists of different levels of difficulty using predesigned paper-and-pencil exercises. Also, to evaluate the effects of the cognitive training on patients' with early stage of Alzheimer's disease.
METHODS
The subjects for this study were forty participants who were diagnosed with early stage of Alzheimer's dementia. To test the efficacy of paper-based cognitive training programs to cognition, all patients were randomly grouped to either an intervention group (n=20) or a control group (n=20). The intervention group regularly received 24 sessions of paper-based cognitive training over a 12-week period. Neuropsychological examinations were conducted before and after this training period.
RESULTS
After the 12 weeks, the intervention group showed a significant change in Korean version of the Mini-Mental State Examination (25.90±3.8), compared to the control group (23.7±2.8) (p=0.042). The training group also showed a significant improvement in language, attention and executive function, as compared with controls.
CONCLUSIONS
Paper-based cognitive training might have beneficial effects on the general cognitive functions in the early stage of Alzheimer's dementia.

Keyword

Alzheimer's Disease; Cognitive Behavioral Therapy; Cognition; Neurocognitive Disorders; Neuropsychological Test

MeSH Terms

Alzheimer Disease
Cognition
Cognitive Therapy
Dementia*
Education
Executive Function
Exercise
Humans
Neurocognitive Disorders
Neuropsychological Tests

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Reference

1. Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017; 390:2673–2734.
Article
2. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013; 9:63–75.e2.
Article
3. Karakaya T, Fußer F, Schröder J, Pantel J. Pharmacological treatment of mild cognitive impairment as a prodromal syndrome of Alzheimer's disease. Curr Neuropharmacol. 2013; 11:102–108.
Article
4. Muayqil T, Camicioli R. Systematic review and meta-analysis of combination therapy with cholinesterase inhibitors and memantine in Alzheimer's disease and other dementias. Dement Geriatr Cogn Dis Extra. 2012; 2:546–572.
Article
5. Buschert V, Bokde AL, Hampel H. Cognitive intervention in Alzheimer disease. Nat Rev Neurol. 2010; 6:508–517.
Article
6. García-Casal JA, Loizeau A, Csipke E, Franco-Martín M, Perea-Bartolomé MV, Orrell M. Computer-based cognitive interventions for people living with dementia: a systematic literature review and meta-analysis. Aging Ment Health. 2017; 21:454–467.
Article
7. Clare L, Woods RT, Moniz Cook ED, Orrell M, Spector A. Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia. Cochrane Database Syst Rev. 2003; CD003260.
Article
8. Belleville S, Clément F, Mellah S, Gilbert B, Fontaine F, Gauthier S. Training-related brain plasticity in subjects at risk of developing Alzheimer's disease. Brain. 2011; 134:1623–1634.
Article
9. Spironelli C, Bergamaschi S, Mondini S, Villani D, Angrilli A. Functional plasticity in Alzheimer's disease: effect of cognitive training on language-related ERP components. Neuropsychologia. 2013; 51:1638–1648.
Article
10. Kallio EL, Öhman H, Kautiainen H, Hietanen M, Pitkälä K. Cognitive training interventions for patients with Alzheimer's disease: a systematic review. J Alzheimers Dis. 2017; 56:1349–1372.
Article
11. Yang Y, Kwak YT. Improvement of cognitive function after computer-based cognitive training in early stage of Alzheimer's dementia. Dement Neurocogn Disord. 2017; 16:7–11.
Article
12. Jelcic N, Cagnin A, Meneghello F, Turolla A, Ermani M, Dam M. Effects of lexical-semantic treatment on memory in early Alzheimer disease: an observer-blinded randomized controlled trial. Neurorehabil Neural Repair. 2012; 26:949–956.
Article
13. Shao YK, Mang J, Li PL, Wang J, Deng T, Xu ZX. Computer-based cognitive programs for improvement of memory, processing speed and executive function during age-related cognitive decline: a meta-analysis. PLoS One. 2015; 10:e0130831.
Article
14. Tsolaki M, Poptsi E, Aggogiatou C, Markou N, Zafeiropoulos S, Kounti F. Computer-based cognitive training versus paper and pencil training: which is more effective? A randomized controlled trial in people with mild cognitive impairment. JSM Alzheimers Dis Relat Dement. 2017; 4:1032.
15. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984; 34:939–944.
Article
16. Morris JC. Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. Int Psychogeriatr. 1997; 9:Suppl 1. 173–176.
Article
17. Han C, Jo SA, Jo I, Kim E, Park MH, Kang Y. An adaptation of the Korean mini-mental state examination (K-MMSE) in elderly Koreans: demographic influence and population-based norms (the AGE study). Arch Gerontol Geriatr. 2008; 47:302–310.
Article
18. Kang YW, Na DL. Seoul Neuropsychological Screening Battery. Seoul: Human Brain Research & Consulting Co.;2003.
19. Kim H, Na DL. Normative data on the Korean version of the Boston Naming Test. J Clin Exp Neuropsychol. 1999; 21:127–133.
20. Fastenau PS, Denburg NL, Hufford BJ. Adult norms for the Rey-Osterrieth Complex Figure Test and for supplemental recognition and matching trials from the Extended Complex Figure Test. Clin Neuropsychol. 1999; 13:30–47.
Article
21. Kang YW, Chin JH, Na DL, Lee JH, Park JS. A normative study of the Korean version of Controlled Oral Word Association Test (COWAT) in elderly. Korean J Clin Psychol. 2000; 19:385–392.
22. Lee JH, Kang YW, Na DL. Efficiencies of stroop interference indexes in healthy older adults and dementia patients. Korean J Clin Psychol. 2000; 19:807–818.
23. Hwang HR, Choi SH, Yoon DH, Yoon BN, Suh YJ, Lee D, et al. The effect of cognitive training in patients with mild cognitive impairment and early Alzheimer’s disease: a preliminary study. J Clin Neurol. 2012; 8:190–197.
Article
24. Cavallo M, Hunter EM, van der Hiele K, Angilletta C. Computerized structured cognitive training in patients affected by early-stage Alzheimer's disease is feasible and effective: a randomized controlled study. Arch Clin Neuropsychol. 2016.
Article
25. Li B, Zhu X, Hou J, Chen T, Wang P, Li J. Combined cognitive training vs. memory strategy training in healthy older adults. Front Psychol. 2016; 7:834.
Article
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