Psychiatry Investig.  2019 May;16(5):397-402. 10.30773/pi.2019.02.26.4.

Examining Patterns of Polypharmacy in Bipolar Disorder: Findings from the REAP-BD, Korea

  • 1Department of Psychiatry, Veteran Health Service Medical Center, Seoul, Republic of Korea.
  • 2Department of Psychiatry, Jeju National University, Jeju, Republic of Korea.
  • 3Department of Psychiatry, Incheon Chamsarang Hospital, Incheon, Republic of Korea.
  • 4Department of Neuropsychiatry, Hanyang University Guri Hospital, Guri, Republic of Korea.
  • 5Department of Psychiatry, Bugok National Hospital, Changyeong, Republic of Korea.
  • 6Department of Psychiatry, Chosun University Hosptial, Gwangju, Republic of Korea.
  • 7Department of Psychiatry, Konyang University Hospital, Daejeon, Republic of Korea.
  • 8Department of Psychiatry, Korea University Anam Hospital, Seoul, Republic of Korea.
  • 9Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, Republic of Korea.
  • 10Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.
  • 11Department of Pharmacology, National University Hospital, Singapore, Singapore.
  • 12Department of Social Welfare, School of Human Sciences, Seinan Gakuin University, Fukuoka, Japan.


Based on Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar Disorder, this study tried to present prescription patterns in biopolar disorder (BD) and its associated clinical features. Based on the information obtained from the study with structured questions, the tendency of prescription pattern was studied and analyzed. Polypharmacy was predominant, including simple polypharmacy in 51.1% and complex polypharmacy in 34.2% of patients. Subjects associated with simple or complex polypharmacy were significantly younger, had higher inpatient settings, a larger portion of onset with manic episode, a shorter duration of untreated illness, a shorter duration of current episode, were more overweight, used less antidepressants and used more anxiolytics. These findings can suggest higher polypharmacy rate in more severe BD and highlight the necessity of monitoring the weight of subjects with polypharmacy.


Polypharmacy; Bipolar disorder; Inpatient; Antidepressant
Full Text Links
  • PI
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: