Psychiatry Investig.  2019 May;16(5):379-385. 10.30773/pi.2019.02.26.3.

Polymorphisms of Ionotropic Glutamate Receptor-Related Genes and the Risk of Autism Spectrum Disorder in a Chinese Population

• Xie X
• Hou F
• Li L
• Chen Y
• Liu L
• Luo X
• Gu H
• Li X
• Zhang J
• Gong J
• Song R

• KMID: 2449910
• DOI: http://doi.org/10.30773/pi.2019.02.26.3

Abstract

OBJECTIVE
To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population.
METHODS
We performed spatio-temporal expression analysis of GRIK2 and NLGN1 in the developing prefrontal cortex, and examined the expression of the genes in ASD cases and healthy controls using the GSE38322 data set. Following, we performed a case-control study in a Chinese population.
RESULTS
The analysis using the publicly available expression data showed that GRIK2 and NLGN1 may have a role in the development of human brain and contribute to the risk of ASD. Later genetic analysis in the Chinese population showed that the GRIK2 rs6922753 for the T allele, TC genotype and dominant model played a significant protective role in ASD susceptibility (respectively: OR=0.840, p=0.023; OR=0.802, p=0.038; OR=0.791, p=0.020). The NLGN1 rs9855544 for the G allele and GG genotype played a significant protective role in ASD susceptibility (respectively: OR=0.844, p=0.019; OR=0.717, p=0.022). After adjusting p values, the statistical significance was lost (p>0.05).
CONCLUSION
Our results suggested that GRIK2 rs6922753 and NLGN1 rs9855544 might not confer susceptibility to ASD in the Chinese population.

Keyword

Autism spectrum disorder; Ionotropic glutamate receptors; GRIK2; NLGN1; Polymorphism

MeSH Terms

Alleles
Asian Continental Ancestry Group*
Autism Spectrum Disorder*
Autistic Disorder*
Brain
Case-Control Studies
Dataset
Genotype
Glutamic Acid*
Humans
Prefrontal Cortex
Receptors, Ionotropic Glutamate
Glutamic Acid
Receptors, Ionotropic Glutamate