Psychiatry Investig.
2019 May;16(5):325-335. 10.30773/pi.2019.02.11.2.
A Systematic Review and Meta-Analysis of Nonpharmacological Interventions for Moderate to Severe Dementia
- Affiliations
-
- 1National Institute of Dementia, Seongnam, Republic of Korea. kwkimmd@snu.ac.kr
- 2Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
- 3Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
- 4Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
- KMID: 2449904
- DOI: http://doi.org/10.30773/pi.2019.02.11.2
Abstract
OBJECTIVE
Due to limited efficacy of medications, non-pharmacological interventions (NPI) are frequently co-administered to people with moderate to severe dementia (PWMSD). This systematic review and meta-analysis investigated the effects of NPI on activities of daily living (ADL), behavioral and psychological symptoms of dementia (BPSD), and cognition and quality of life (QoL) of PWMSD.
METHODS
A literature search was conducted in the following databases: Cochrane CENTRAL, EMBASE, Medline, CIHNAL, PsycINFO, KoreaMED, KMbase, and KISS. We conducted a meta-analysis on randomized controlled trials and used the generic inverse variance method with a fixed-effects model to calculate the standardized mean difference (SMD). The protocol had been registered (CRD42017058020).
RESULTS
Ten randomized controlled trials met the inclusion criteria of the current meta-analysis. NPI were effective in improving ADL [SMD=0.28, 95% confidence interval (CI)=0.11-0.45] and reducing depression (SMD=-0.44, 95% CI=-0.70- -0.19). However, NPI were not effective in reducing agitation, anxiety, or overall, or improving cognitive function. In a subgroup analysis, music therapy was effective in reducing overall BPSD (SMD=-0.52, 95% CI=-0.90- -0.13).
CONCLUSION
Albeit the number of studies was limited, NPI improved ADL and depression in PWMSD.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Systematic Review of Nonpharmacological Interventions for Moderate to Severe Dementia: A Study Protocol for a Systematic Review and Meta-Analysis
- Non-pharmacological Intervention for Wandering Behavior in Dementia: A Systematic Review and Meta-analysis
- Exploring Factors Associated With Successful Nonpharmacological Interventions for People With Dementia
- Effects of nonpharmacological interventions on the psychological health of high-risk pregnant women: a systematic review and meta-analysis
- Effect of Digital Health Interventions on Psychotic Symptoms among Persons with Severe Mental Illness in Community: A Systematic Review and Meta-Analysis
