Clin Endosc.  2019 May;52(3):252-257. 10.5946/ce.2018.151.

Efficacy of Endoscopic Submucosal Dissection of Esophageal Neoplasms under General Anesthesia

• Hamada K
• Kawano K
• Yamauchi A
• Koyanagi R
• Horikawa Y
• Nishida S
• Shiwa Y
• Nishino N
• Honda M

• KMID: 2449765
• DOI: http://doi.org/10.5946/ce.2018.151

Abstract

BACKGROUND/AIMS
Evidence that general anesthesia (GA) reduces the operative time of esophageal endoscopic submucosal dissection (ESD) is currently insufficient. This study aims to evaluate the efficacy and safety of esophageal ESD under GA.
METHODS
A total of 227 lesions from 198 consecutive patients with superficial esophageal neoplasms treated by ESD at 3 Japanese institutions between April 2011 and September 2017 were included in this retrospective study. For ESD, GA and deep sedation (DS) were used in 102 (51.5%, GA group) and 96 patients (48.5%, DS group), respectively.
RESULTS
There were no statistically significant differences in age, sex, or comorbidities between the groups. In the GA group, the tumor size was larger (21 [3-77] mm vs. 14 [3-63] mm, p<0.001), luminal circumference was larger (≥2/3; 13.9% vs. 5.4%, p=0.042), procedure time was shorter (28 [5-202] min vs. 40 [8-249] min, p<0.001), and submucosal dissection speed was faster (25.2 [7.8-157.2] mm² /min vs. 16.2 [2.4-41.3] mm² /min, p<0.001). The rates of intraoperative perforation and aspiration pneumonia were lower in the GA group, but the difference did not achieve statistical significance (p=0.242 and p=0.242).
CONCLUSIONS
GA shortens the procedure time of esophageal ESD.

Keyword

Esophageal cancer; Endoscopic submucosal dissection; Anesthesia

MeSH Terms

Anesthesia
Anesthesia, General*
Asian Continental Ancestry Group
Comorbidity
Deep Sedation
Esophageal Neoplasms*
Humans
Operative Time
Phenobarbital
Pneumonia, Aspiration
Retrospective Studies
Phenobarbital

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