Yeungnam Univ J Med.  2019 May;36(2):99-104. 10.12701/yujm.2019.00080.

Efficacy of ramosetron in combination with polyethylene glycol of preparing for a colonoscopy

Affiliations
  • 1Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. jbi@med.yu.ac.kr

Abstract

BACKGROUND
Because of its efficacy and safety, polyethylene glycol (PEG) is generally used to prepare for colonoscopy. However, the side effects of PEG, including nausea, vomiting, abdominal discomfort, pain, and general weakness, tend to decrease patient compliance and satisfaction. The aim of this study is to investigate the efficacy and safety of PEG with 0.1 mg ramosetron on colonoscopy patients who had difficulty taking PEG due to side effects or large volume.
METHODS
From January to August in 2012, 28 patients who visited Yeungnam University hospital for a colonoscopy were prospectively enrolled. All enrolled patients were previous history underwent colonoscopy using PEG only in our hospital. The efficacy and safety of ramosetron were assessed through the use of a questionnaire, and compared previous bowel preparation.
RESULTS
Compared to previous examination, the patients using the ramosetron reported less nausea, vomiting, abdominal discomfort, and abdominal pain, as well as a higher degree of compliance and satisfaction of the patient. There were no side effects reported with the use of ramosetron. However, overall bowel preparation quality was not better than the previous examination.
CONCLUSION
In case of the use of ramosetron in combination with PEG for bowel preparation, patients experienced a higher rate of compliance and tolerance. Looking forward, ramosetron may become an option of pretreatment for bowel preparation.

Keyword

Bowel preparation; Colonoscopy; Polyethylene glycol; Ramosetron

MeSH Terms

Abdominal Pain
Colonoscopy*
Compliance
Humans
Nausea
Patient Compliance
Polyethylene Glycols*
Polyethylene*
Prospective Studies
Vomiting
Polyethylene
Polyethylene Glycols

Reference

References

1. Regula J, Rupinski M, Kraszewska E, Polkowski M, Pachlewski J, Orlowska J, et al. Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia. N Engl J Med. 2006; 355:1863–72.
Article
2. Piscatelli N, Hyman N, Osler T. Localizing colorectal cancer by colonoscopy. Arch Surg. 2005; 140:932–5.
Article
3. Sonnenberg A, Delcò F. Cost-effectiveness of a single colonoscopy in screening for colorectal cancer. Arch Intern Med. 2002; 162:163–8.
Article
4. Heitman SJ, Manns BJ, Hilsden RJ, Fong A, Dean S, Romagnuolo J. Cost-effectiveness of computerized tomographic colonography versus colonoscopy for colorectal cancer screening. CMAJ. 2005; 173:877–81.
Article
5. Wexner SD, Beck DE, Baron TH, Fanelli RD, Hyman N, Shen B, et al. A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES). Gastrointest Endosc. 2006; 63:894–909.
Article
6. Rex DK, Bond JH, Winawer S, Levin TR, Burt RW, Johnson DA, et al. Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2002; 97:1296–308.
Article
7. Harewood GC, Sharma VK, de Garmo P. Impact of colonoscopy preparation quality on detection of suspected colonic neoplasia. Gastrointest Endosc. 2003; 58:76–9.
Article
8. Chokshi RV, Hovis CE, Hollander T, Early DS, Wang JS. Prevalence of missed adenomas in patients with inadequate bowel preparation on screening colonoscopy. Gastrointest Endosc. 2012; 75:1197–203.
Article
9. Parra-Blanco A, Nicolas-Perez D, Gimeno-Garcia A, Grosso B, Jimenez A, Ortega J, et al. The timing of bowel preparation before colonoscopy determines the quality of cleansing, and is a significant factor contributing to the detection of flat lesions: a randomized study. World J Gastroenterol. 2006; 12:6161–6.
Article
10. Chiu HM, Lin JT, Lee YC, Liang JT, Shun CT, Wang HP, et al. Different bowel preparation schedule leads to different diagnostic yield of proximal and nonpolypoid colorectal neoplasm at screening colonoscopy in average-risk population. Dis Colon Rectum. 2011; 54:1570–7.
Article
11. Sharara AI, Abou Mrad RR. The modern bowel preparation in colonoscopy. Gastroenterol Clin North Am. 2013; 42:577–98.
Article
12. Jones RM, Devers KJ, Kuzel AJ, Woolf SH. Patient-reported barriers to colorectal cancer screening: a mixed-methods analysis. Am J Prev Med. 2010; 38:508–16.
13. Jover R, Zapater P, Polanía E, Bujanda L, Lanas A, Hermo JA, et al. Modifiable endoscopic factors that influence the adenoma detection rate in colorectal cancer screening colonoscopies. Gastrointest Endosc. 2013; 77:381–9.
Article
14. Burke CA, Church JM. Enhancing the quality of colonoscopy: the importance of bowel purgatives. Gastrointest Endosc. 2007; 66:565–73.
Article
15. ASHP therapeutic guidelines on the pharmacologic management of nausea and vomiting in adult and pediatric patients receiving chemotherapy or radiation therapy or undergoing surgery. Am J Health Syst Pharm. 1999; 56:729–64.
16. Gan TJ, Diemunsch P, Habib AS, Kovac A, Kranke P, Meyer TA, et al. Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2014; 118:85–113.
Article
17. Chan CH, Diner WC, Fontenot E, Davidson BD. Randomized single-blind clinical trial of a rapid colonic lavage solution (Golytely) vs. standard preparation for barium enema and colonoscopy. Gastrointest Radiol. 1985; 10:378–82.
Article
18. Burke DA, Manning AP, Murphy L, Axon AT. Oral bowel lavage preparation for colonoscopy. Postgrad Med J. 1988; 64:772–4.
Article
19. Adler M, Quenon M, Even-Adin D, Jeanmart J, Van Gossum A, Bourgeois N, et al. Whole gut lavage for colonoscopy--a comparison between two solutions. Gastrointest Endosc. 1984; 30:65–7.
Article
20. Beck DE, Fazio VW, Jagelman DG. Comparison of oral lavage methods for preoperative colonic cleansing. Dis Colon Rectum. 1986; 29:699–703.
Article
21. Marshall JB, Pineda JJ, Barthel JS, King PD. Prospective, randomized trial comparing sodium phosphate solution with polyethylene glycol-electrolyte lavage for colonoscopy preparation. Gastrointest Endosc. 1993; 39:631–4.
Article
22. Abdullah M, Rani AA, Fauzi A, Syam AF, Makmun D, Simadibrata M, et al. A randomized, controlled, double-blind trial of the adjunct use of Clebopride in polyethylene glycol electrolyte (PEG) solution for colonoscopy preparation. Acta Med Indones. 2010; 42:27–30.
23. Tajika M, Niwa Y, Bhatia V, Kawai H, Kondo S, Sawaki A, et al. Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation. World J Gastroenterol. 2012; 18:2517–25.
Article
24. Rabasseda X. Ramosetron, a 5-HT3 receptor antagonist for the control of nausea and vomiting. Drugs Today (Barc). 2002; 38:75–89.
Article
25. Kim WO, Koo BN, Kim YK, Kil HK. Ramosetron for the prevention of postoperative nausea and vomiting (PONV): a meta-analysis. Korean J Anesthesiol. 2011; 61:405–12.
Article
26. Ohta M, Suzuki T, Furuya T, Kurihara H, Tokunaga T, Miyata K, et al. Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. III. Pharmacological evaluations and molecular modeling studies of optically active 4,5,6,7-tetrahydro-1H-benzimidazole derivatives. Chem Pharm Bull (Tokyo). 1996; 44:1707–16.
Article
27. Kim KR, Kang G, Ki MS, Shim HJ, Hwang JE, Bae WK, et al. A randomized, double-blind pilot study of dose comparison of ramosetron to prevent chemotherapy-induced nausea and vomiting. Biomed Res Int. 2015; 2015:523601.
Article
28. Rostom A, Jolicoeur E, Dubé C, Grégoire S, Patel D, Saloojee N, et al. A randomized prospective trial comparing different regimens of oral sodium phosphate and polyethylene glycol-based lavage solution in the preparation of patients for colonoscopy. Gastrointest Endosc. 2006; 64:544–52.
Article
29. Brady CE 3rd, DiPalma JA, Pierson WP. Golytely lavage--is metoclopramide necessary? Am J Gastroenterol. 1985; 80:180–4.
30. Rhodes JB, Engstrom J, Stone KF. Metoclopramide reduces the distress associated with colon cleansing by an oral electrolyte overload. Gastrointest Endosc. 1978; 24:162–3.
Article
31. Froehlich F, Fried M, Schnegg JF, Gonvers JJ. Low sodium solution for colonic cleansing: a double-blind, controlled, randomized prospective study. Gastrointest Endosc. 1992; 38:579–81.
Article
32. Huppertz-Hauss G, Bretthauer M, Sauar J, Paulsen J, Kjellevold Ø, Majak B, et al. Polyethylene glycol versus sodium phosphate in bowel cleansing for colonoscopy: a randomized trial. Endoscopy. 2005; 37:537–41.
Article
Full Text Links
  • YUJM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr