Korean J Pancreas Biliary Tract.  2015 Jul;20(3):115-123. 10.15279/kpba.2015.20.3.115.

Mechanism of Severe Acute Pancreatitis: Focusing on Development and Progression

Affiliations
  • 1Division of Gastroenterology, Department of Internal Medicine, Chung-Ang University School of Medicine, Seoul, Korea. jhdo@cau.ac.kr

Abstract

Acute pancreatitis (AP) is an inflammatory disorder and the severity range from mild to severe form. The mortality of severe form of AP is still high despite of tremendous improvement of diagnostic modalities and therapeutic options. Although pathogenesis of AP is still not fully understood, autodigestion theory is regarded as an initial common pathophysiologic mechanism of AP for about 2 centuries. However, it is obscure which mechanisms are involving the disease severity. Upregulation of adhesion molecules, leukocytes, proinflammatory cytokines and chemokines are also concerned local injury, systemic exacerbation of inflammation and ultimately organ failure. In addition, transcription factor Nuclear factor-kappa B is also influence the severity through upregulate the proinflammatory genes. The patterns of acinar cell death are closely correlated with disease severity of AP. The degree of acinar cell apoptosis is reversed correlated whereas necrotic cell death is proportionate to severity.

Keyword

Severe acute pancreatitis; Pathogenesis; Organ failure; Pancreatic infection

MeSH Terms

Acinar Cells
Apoptosis
Cell Death
Chemokines
Cytokines
Inflammation
Leukocytes
Mortality
Pancreatitis*
Transcription Factors
Up-Regulation
Chemokines
Cytokines
Transcription Factors
Full Text Links
  • KJPBT
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr