Korean J Vet Res.  2019 Mar;59(1):9-15. 10.14405/kjvr.2019.59.1.9.

Serum concentrations of α2-macroglobulin, α1-antitrypsin, and C-reactive protein in dogs with suspected acute pancreatitis

Affiliations
  • 1Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea. mpyang@chungbuk.ac.kr
  • 2Laboratory of Veterinary Internal Medicine and Neuroendocrinology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea. jhkang@chungbuk.ac.kr
  • 3Laboratory of Veterinary Dermatology and Neurology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea.

Abstract

In canine acute pancreatitis (AP), inappropriate release and activation of zymogen proteases within the pancreas results in the consumption of serum antiproteases. The aim of this study was to examine whether the serum concentrations of α₂-macroglobulin (A2MG), α₁-antitrypsin (A1AT), and C-reactive protein (CRP) differ between dogs with AP and healthy dogs. Twenty healthy dogs and 20 dogs with AP were included in this study. Concentrations of A2MG, A1AT, and CRP were measured in the sera of healthy dogs and dogs diagnosed with AP. Serum A2MG and A1AT concentrations were significantly lower in dogs with AP than in healthy dogs, whereas the serum CRP concentration was significantly higher. In addition, the concentrations of A2MG and A1AT were significantly higher in AP survivors than in AP non-survivors, while the CRP concentration was significantly lower. However, in both AP survivors and non-survivors, the CRP concentrations showed a negative correlation with A2MG concentrations but not with A1AT. These findings indicate that serum antiproteases and CRP concentrations might be associated with the mortality rate of AP in dogs.

Keyword

C-reactive protein; pancreas; protease inhibitor; trypsin

MeSH Terms

Animals
C-Reactive Protein*
Dogs*
Humans
Mortality
Pancreas
Pancreatitis*
Peptide Hydrolases
Protease Inhibitors
Survivors
Trypsin
C-Reactive Protein
Peptide Hydrolases
Protease Inhibitors
Trypsin
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