Korean J Gastroenterol.  2019 May;73(5):294-298. 10.4166/kjg.2019.73.5.294.

Management of Achalasia: Expert Consensus Statements

Affiliations
  • 1Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea. junghk@ewha.ac.kr

Abstract

Achalasia is a motility disorder of the esophagus characterized by absence of peristalsis and failure of relaxation of lower esophagus sphincter. The introduction of high resolution manometry (HRM) and per-oral endoscopic myotomy (POEM) has made a new chapter in diagnosis and treatment of achalasia. HRM allows classify according to the subtype of achalasia, and help predict prognosis and therapeutic response. POEM is a minimally invasive, effective option for treating achalasia. The management of achalasia required tailored application of various therapies such as botox injection, pneumatic balloon dilatation, POEM, or Heller's myotomy. In this review, we state the important aspects of diagnosis as well as management of achalasia.

Keyword

Esophageal achalasia; Manometry; Myotomy

MeSH Terms

Consensus*
Diagnosis
Dilatation
Esophageal Achalasia*
Esophagus
Manometry
Peristalsis
Prognosis
Relaxation

Figure

  • Fig. 1 Achalasia subtypes according to Chicago classification in high resolution manometry. (A) Type I achalasia. (B) Type II achalasia. (C) Type III achalasia.


Reference

1. Pandolfino JE, Kwiatek MA, Nealis T, Bulsiewicz W, Post J, Kahrilas PJ. Achalasia: a new clinically relevant classification by high-resolution manometry. Gastroenterology. 2008; 135:1526–1533.
Article
2. Ramchandani M, Nageshwar Reddy D, Nabi Z, et al. Management of achalasia cardia: expert consensus statements. J Gastroenterol Hepatol. 2018; 33:1436–1444.
Article
3. Kahrilas PJ, Bredenoord AJ, Fox M, et al. The Chicago classification of esophageal motility disorders, v3.0. Neurogastroenterol Motil. 2015; 27:160–174.
Article
4. Roman S, Zerbib F, Quenehervé L, Clermidy H, Varannes SB, Mion F. The Chicago classification for achalasia in a French multicentric cohort. Dig Liver Dis. 2012; 44:976–980.
Article
5. Rohof WO, Salvador R, Annese V, et al. Outcomes of treatment for achalasia depend on manometric subtype. Gastroenterology. 2013; 144:718–725.
Article
6. Schlottmann F, Luckett DJ, Fine J, Shaheen NJ, Patti MG. Laparoscopic Heller myotomy versus peroral endoscopic myotomy (POEM) for achalasia: a systematic review and metaanalysis. Ann Surg. 2018; 267:451–460.
7. Chan SM, Wu JC, Teoh AY, et al. Comparison of early outcomes and quality of life after laparoscopic Heller's cardiomyotomy to peroral endoscopic myotomy for treatment of achalasia. Dig Endosc. 2016; 28:27–32.
Article
8. Docimo S Jr, Mathew A, Shope AJ, Winder JS, Haluck RS, Pauli EM. Reduced postoperative pain scores and narcotic use favor per-oral endoscopic myotomy over laparoscopic Heller myotomy. Surg Endosc. 2017; 31:795–800.
Article
9. Khashab MA, Messallam AA, Onimaru M, et al. International multicenter experience with peroral endoscopic myotomy for the treatment of spastic esophageal disorders refractory to medical therapy (with video). Gastrointest Endosc. 2015; 81:1170–1177.
10. Khan MA, Kumbhari V, Ngamruengphong S, et al. Is POEM the answer for management of spastic esophageal disorders? A systematic review and meta-analysis. Dig Dis Sci. 2017; 62:35–44.
Article
11. Zaninotto G, Annese V, Costantini M, et al. Randomized controlled trial of botulinum toxin versus laparoscopic Heller myotomy for esophageal achalasia. Ann Surg. 2004; 239:364–370.
Article
12. Pasricha PJ, Ravich WJ, Hendrix TR, Sostre S, Jones B, Kalloo AN. Treatment of achalasia with intrasphincteric injection of botulinum toxin. A pilot trial. Ann Intern Med. 1994; 121:590–591.
Article
13. Bassotti G, Annese V. Review article: pharmacological options in achalasia. Aliment Pharmacol Ther. 1999; 13:1391–1396.
Article
14. Ghoshal UC, Rangan M. A review of factors predicting outcome of pneumatic dilation in patients with achalasia cardia. J Neurogastroenterol Motil. 2011; 17:9–13.
Article
15. Zaninotto G, Costantini M, Portale G, et al. Etiology, diagnosis, and treatment of failures after laparoscopic Heller myotomy for achalasia. Ann Surg. 2002; 235:186–192.
Article
16. Ellis FG. The natural history of achalasia of the cardia. Proc R Soc Med. 1960; 53:663–666.
17. Inoue H, Shiwaku H, Iwakiri K, et al. Clinical practice guidelines for peroral endoscopic myotomy. Dig Endosc. 2018; 30:563–579.
Article
18. Duranceau A, Liberman M, Martin J, Ferraro P. End-stage achalasia. Dis Esophagus. 2012; 25:319–330.
Article
19. Neyaz Z, Gupta M, Ghoshal UC. How to perform and interpret timed barium esophagogram. J Neurogastroenterol Motil. 2013; 19:251–256.
Article
20. Ghoshal UC, Kumar S, Saraswat VA, Aggarwal R, Misra A, Choudhuri G. Long-term follow-up after pneumatic dilation for achalasia cardia: factors associated with treatment failure and recurrence. Am J Gastroenterol. 2004; 99:2304–2310.
Article
21. Eckardt VF, Gockel I, Bernhard G. Pneumatic dilation for achalasia: late results of a prospective follow up investigation. Gut. 2004; 53:629–633.
Article
Full Text Links
  • KJG
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr