Korean J Fam Med.  2019 Mar;40(2):124-128. 10.4082/kjfm.17.0068.

Serum Alanine Aminotransferase Level as a Risk Factor for Coronary Heart Disease Prediction in Koreans: Analysis of the Korea National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011)

• Kim K
• Kim D
• Kim KN

• KMID: 2447090
• DOI: http://doi.org/10.4082/kjfm.17.0068

Abstract

BACKGROUND
The blood level of alanine aminotransferase (ALT) is associated with increased coronary heart disease (CHD) risk. However, its use as an independent factor for CHD risk prediction remains unclear in Asian populations. The purpose of this study was to examine the association between serum ALT levels and CHD risk in Koreans.
METHODS
This was a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011). The ALT levels of 3,215 individuals were analyzed. The Framingham Risk Score (FRS) modified by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) was used to compute the 10-year CHD risk prediction.
RESULTS
Positive correlations were established between log-transformed ALT concentration and FRS (r=0.433, P<0.001). After adjusting for body mass index, low-density lipoprotein cholesterol, the amount of alcohol intake, and gamma-glutamyl transferase, the odds ratio (95% confidence interval) for intermediate or greater risk of 10- year CHD prediction (10-year risk ≥10%) for the lowest quartile of participants was 2.242 (1.405-3.577) for the second quartile, 2.879 (1.772-4.679) for the third quartile, and 3.041 (1.789-5.170) for the highest quartile.
CONCLUSION
In Koreans, a higher serum ALT concentration was significantly correlated with 10-year CHD risk prediction according to NCEP ATP III guidelines.

Keyword

Alanine Aminotransferase; Coronary Disease; Framingham Risk Score

MeSH Terms

Adenosine Triphosphate
Adult
Alanine Transaminase*
Alanine*
Asian Continental Ancestry Group
Body Mass Index
Cholesterol
Coronary Disease*
Cross-Sectional Studies
Education
Humans
Korea*
Lipoproteins
Nutrition Surveys*
Odds Ratio
Risk Factors*
Transferases
Adenosine Triphosphate
Alanine
Alanine Transaminase
Cholesterol
Lipoproteins
Transferases