Korean J Fam Med.  2019 Mar;40(2):93-99. 10.4082/kjfm.17.0083.

Association of Lung Function with Serum 25-Hydroxyvitamin D Level according to the Presence of Past Pulmonary Tuberculosis in Korean Adults

Affiliations
  • 1Department of Family Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. fmchcj@catholic.ac.kr

Abstract

BACKGROUND
Vitamin D deficiency is associated with an increased risk of pulmonary tuberculosis (PTB) infection and the treatment outcome. The aim of this study was to examine the relationship between the serum 25-hydroxyvitamin D (25[OH]D) level and lung function in Korean adults according to whether or not there is a history of PTB.
METHODS
The data for subjects aged 19 years or older from the Korea National Health and Nutrition Examination Survey 2008-2012 who underwent spirometry, chest radiography, and serum 25(OH)D level measurement were analyzed.
RESULTS
Evidence of past PTB infection was found in 1,482 (9.6%) of 15,516 subjects. The serum 25(OH)D level was lower in the group with past PTB than in the non-PTB group (P=0.013). Respiratory dysfunction was more common in the past PTB group than in the non-PTB group (restrictive pattern, 14.0% vs. 9.6%; obstructive pattern, 29.6% vs. 8.2%; both P<0.001). After adjusting for age, sex, height, and season, the mean difference in forced expiratory volume in 1 second (FEV1) between the highest and lowest quartiles of 25(OH)D was 100.2 mL (standard error= 49.3 mL, P for trend=0.049) in the past PTB group and 34.7 mL (standard error=13.6 mL, P=0.009) in the non-PTB group.
CONCLUSION
FEV1 tended to increase as the vitamin D quartile increased in both study groups. This relationship was more pronounced in subjects with a history of PTB. A higher serum 25(OH)D level might be beneficial in preserving lung function after PTB infection.

Keyword

Mass Chest X-Ray; Spirometry; Lung Function; Tuberculosis; Vitamin D; Korea

MeSH Terms

Adult*
Forced Expiratory Volume
Humans
Korea
Lung*
Mass Chest X-Ray
Nutrition Surveys
Radiography
Seasons
Spirometry
Thorax
Treatment Outcome
Tuberculosis
Tuberculosis, Pulmonary*
Vitamin D
Vitamin D Deficiency
Vitamin D
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